Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| D6RIW1 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | Homo sapiens (Human) | 95 aa |
Protein Details: D6RIW1 (HMGCS1)
Protein Information
| Accession | D6RIW1 |
|---|---|
| Protein Names | 3-hydroxy-3-methylglutaryl-CoA synthase 1 |
| Gene Symbol | HMGCS1 |
| Organism | Homo sapiens (Human) |
| Length | 95 aa |
| Isoforms | No isoforms |
| Related PMIDs | 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPGSLPLNAE11ACWPKDVGIV21ALEIYFPSQY31VDQAELEKYD41GVDAGKYTIG
51-9551LGQAKMGFCT61DREDINSLCM71TVVQNLMERN81NLSYDCIGRL91EVGTE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | - | - | - |
Deep-Palm: 0.11
|
|
| 59 | - | - | - |
Deep-Palm: 0.90
|
|
| 69 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.27
|
|
| 86 | - | - | - |
Deep-Palm: 0.17
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
PC3
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 84 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 268 | C → S | 0.001969 | SNP | Missense Mutation | HNSC |
| 352 | S → C | 0.003559 | SNP | Missense Mutation | KIRP |