Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E5RK63 | ANXA6 | Annexin | Homo sapiens (Human) | 150 aa |
Protein Details: E5RK63 (ANXA6)
Protein Information
| Accession | E5RK63 |
|---|---|
| Protein Names | Annexin |
| Gene Symbol | ANXA6 |
| Organism | Homo sapiens (Human) |
| Length | 150 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKGFGSDKEA11ILDIITSRSN21RQRQEVCQSY31KSLYGKDLIA41DLKYELTGKF
51-10051ERLIVGLMRP61PAYCDAKEIK71DAISGIGTDE81KCLIEILASR91TNEQMHQLVA
101-150101AYKDAYERDL111EADIIGDTSG121HFQKMLVVLL131QGTREEDDVV141SEDLVQQDVQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 27 | ANNEXIN Annexin superfamily Annexin repeat | - | - |
Deep-Palm: 0.97
|
|
| 64 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.94
|
|
| 82 | SWISSPALM DBPTM CYSMODDB | Annexin |
HeLa
(29575903)
|
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.78
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
PC3
Specificity: 0.444
4/4 (100.0%)
3
cerebral cortex
Specificity: 0.333
3/3 (100.0%)
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 59 | C → C | 0.001887 | SNP | Silent | UCEC |
| 206 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 206 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 248 | C → Y | 0.002294 | SNP | Missense Mutation | OV |
| 302 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 393 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 669 | C → R | 0.001887 | SNP | Missense Mutation | UCEC |