Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7EMK3 | FLOT2 | Flotillin | Homo sapiens (Human) | 483 aa |
Protein Details: E7EMK3 (FLOT2)
Protein Information
| Accession | E7EMK3 |
|---|---|
| Protein Names | Flotillin |
| Gene Symbol | FLOT2 |
| Organism | Homo sapiens (Human) |
| Length | 483 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 32944167 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.880
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
44
LNCaP cells
Specificity: 0.880
44/46 (95.7%)
4
PC3 cells
Specificity: 0.080
4/4 (100.0%)
1
HeLa cells
Specificity: 0.020
1/1 (100.0%)
1
Cerebral cortex
Specificity: 0.020
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGNCHTVGPN11EALVVSGGCC21GSDYKQYVFG31GWAWAWWCIS41DTQRLSLEVM
51-10051TILCRCENIE61TSEGVPLFVT71GVAQVPCPCL81LDCKWGNSKG91FWKLCQVCQI
101-150101SLEIMTLQPR111CEDVETAEGV121ALTVTGVAQV131KIMTEKELLA141VACEQFLGKN
151-200151VQDIKNVVLQ161TLEGHLRSIL171GTLTVEQIYQ181DRDQFAKLVR191EVAAPDVGRM
201-250201GIEILSFTIK211DVYDKVDYLS221SLGKTQTAVV231QRDADIGVAE241AERDAGIREA
251-300251ECKKEMLDVK261FMADTKIADS271KRAFELQKSA281FSEEVNIKTA291EAQLAYELQG
301-350301AREQQKIRQE311EIEIEVVQRK321KQIAVEAQEI331LRTDKELIAT341VRRPAEAEAH
351-400351RIQQIAEGEK361VKQVLLAQAE371AEKIRKIGEA381EAAVIEAMGK391AEAERMKLKA
401-450401EAYQKYGDAA411KMALVLEALP421QIAAKIAAPL431TKVDEIVVLS441GDNSKVTSEV
451-483451NRLLAELPAS461VHALTGVDLS471KIPLIKKATG481VQV
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 4 | Prediction (High) | - | - |
| 19 | Prediction (Low) | - | - |
| 38 | Prediction (Low) | - | - |
| 54 | Prediction (Low) | - | - |
| 77 | Prediction (Medium) | - | - |
| 79 | Prediction (Medium) | - | - |
| 83 | Prediction (Low) | - | - |
| 95 | Prediction (Low) | - | - |
| 143 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
| 252 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 55 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 191 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 247 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 287 | R → C | 0.002288 | SNP | Missense Mutation | STAD |