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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
E7EMK3 FLOT2 Flotillin Homo sapiens (Human) 483 aa

Protein Details: E7EMK3 (FLOT2)

Protein Information
AccessionE7EMK3
Protein NamesFlotillin
Gene SymbolFLOT2
OrganismHomo sapiens (Human)
Length483 aa
IsoformsNo isoforms
Related PMIDs 19137006 19801377 29575903 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MGNCHTVGPN11EALVVSGGCC21GSDYKQYVFG31GWAWAWWCIS41DTQRLSLEVM
51-10051TILCRCENIE61TSEGVPLFVT71GVAQVPCPCL81LDCKWGNSKG91FWKLCQVCQI
101-150101SLEIMTLQPR111CEDVETAEGV121ALTVTGVAQV131KIMTEKELLA141VACEQFLGKN
151-200151VQDIKNVVLQ161TLEGHLRSIL171GTLTVEQIYQ181DRDQFAKLVR191EVAAPDVGRM
201-250201GIEILSFTIK211DVYDKVDYLS221SLGKTQTAVV231QRDADIGVAE241AERDAGIREA
251-300251ECKKEMLDVK261FMADTKIADS271KRAFELQKSA281FSEEVNIKTA291EAQLAYELQG
301-350301AREQQKIRQE311EIEIEVVQRK321KQIAVEAQEI331LRTDKELIAT341VRRPAEAEAH
351-400351RIQQIAEGEK361VKQVLLAQAE371AEKIRKIGEA381EAAVIEAMGK391AEAERMKLKA
401-450401EAYQKYGDAA411KMALVLEALP421QIAAKIAAPL431TKVDEIVVLS441GDNSKVTSEV
451-483451NRLLAELPAS461VHALTGVDLS471KIPLIKKATG481VQV
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
4 - - -
GPS-Palm: 0.95
Deep-Palm: 0.03
19 - - -
GPS-Palm: 0.73
Deep-Palm: 0.76
20 - -
Jurkat T (32651440)
Deep-Palm: 0.69
38 - - -
GPS-Palm: 0.71
Deep-Palm: 0.19
54 - -
cerebral cortex (36430497)
GPS-Palm: 0.74
Deep-Palm: 0.87
56 - - -
Deep-Palm: 0.86
77 - - -
GPS-Palm: 0.87
Deep-Palm: 0.81
79 - - -
GPS-Palm: 0.80
Deep-Palm: 0.78
83 - - -
GPS-Palm: 0.65
Deep-Palm: 0.35
95 - - -
GPS-Palm: 0.75
Deep-Palm: 0.60
98 - - -
Deep-Palm: 0.27
111 - -
cerebral cortex (36430497)
LNCaP (31251020)
Deep-Palm: 0.91
143 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
cerebral cortex (36430497)
LNCaP (31251020)
Unknown (32651440)
GPS-Palm: 0.72
Deep-Palm: 0.97
252 SWISSPALM DBPTM CYSMODDB -
HeLa (29575903)
-
GPS-Palm: 0.79
Deep-Palm: 0.90
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
LNCaP
Specificity: 0.267
4/4 (100.0%)
4
PC3
Specificity: 0.267
4/4 (100.0%)
2
HeLa cell
Specificity: 0.133
2/2 (100.0%)
2
Jurkat T cell
Specificity: 0.133
2/2 (100.0%)
1
DU145 cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP cells (Mass)
Specificity: 0.067
1/4 (25.0%)
1
Cerebral Cortex (Mass)
Specificity: 0.067
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
55 R → C 0.003460 SNP Missense Mutation CESC
191 G → C 0.001887 SNP Missense Mutation UCEC
247 R → C 0.002288 SNP Missense Mutation STAD
287 R → C 0.002288 SNP Missense Mutation STAD