Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7ENZ3 | CCT5 | T-complex protein 1 subunit epsilon … | Homo sapiens (Human) | 486 aa |
Protein Details: E7ENZ3 (CCT5)
Protein Information
| Accession | E7ENZ3 |
|---|---|
| Protein Names | T-complex protein 1 subunit epsilon (CCT-epsilon) |
| Gene Symbol | CCT5 |
| Organism | Homo sapiens (Human) |
| Length | 486 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 22496122 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASMGTLAFD11EYGRPFLIIK21DQDRKSRLMG31LEALKSHIMA41AKAVANTMRT
51-10051SLGPNVLAGA61LLEEAEQLLD71RGIHPIRIAD81GYEQAARVAI91EHLDKISDSV
101-150101LVDIKDTEPL111IQTAKTTLGS121KVVNSCHRQM131AEIAVNAVLT141VADMERRDVD
151-200151FELIKVEGKV161GGRLEDTKLI171KGVIVDKDFS181HPQMPKKVED191AKIAILTCPF
201-250201EPPKPKTKHK211LDVTSVEDYK221ALQKYEKEKF231EEMIQQIKET241GANLAICQWG
251-300251FDDEANHLLL261QNNLPAVRWV271GGPEIELIAI281ATGGRIVPRF291SELTAEKLGF
301-350301AGLVQEISFG311TTKDKMLVIE321QCKNSRAVTI331FIRGGNKMII341EEAKRSLHDA
351-400351LCVIRNLIRD361NRVVYGGGAA371EISCALAVSQ381EADKCPTLEQ391YAMRAFADAL
401-450401EVIPMALSEN411SGMNPIQTMT421EVRARQVKEM431NPALGIDCLH441KGTNDMKQQH
451-486451VIETLIGKKQ461QISLATQMVR471MILKIDDIRK481PGESEE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 126 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.82
|
|
| 198 | SWISSPALM DBPTM CYSMODDB | TCP-1/cpn60 chaperonin family | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.97
|
| 247 | - | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.91
Deep-Palm: 0.86
|
|
| 322 | - | - | - |
Deep-Palm: 0.65
|
|
| 352 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.92
|
|
| 374 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.83
|
|
| 385 | - | - | - |
Deep-Palm: 0.92
|
|
| 438 | - | - | - |
Deep-Palm: 0.70
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
2
LNCaP
Specificity: 0.154
2/2 (100.0%)
2
Jurkat T cell
Specificity: 0.154
2/2 (100.0%)
1
EC cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 12 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 386 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 429 | C → C | 0.027027 | SNP | Silent | DLBC |
| 534 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |