Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7EQV3 | PABPC1 | Polyadenylate-binding protein (PABP) | Homo sapiens (Human) | 591 aa |
Protein Details: E7EQV3 (PABPC1)
Protein Information
| Accession | E7EQV3 |
|---|---|
| Protein Names | Polyadenylate-binding protein (PABP) |
| Gene Symbol | PABPC1 |
| Organism | Homo sapiens (Human) |
| Length | 591 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MITRRSLGYA11YVNFQQPADA21ERALDTMNFD31VIKGKPVRIM41WSQRDPSLRK
51-10051SGVGNIFIKN61LDKSIDNKAL71YDTFSAFGNI81LSCKVVCDEN91GSKGYGFVHF
101-150101ETQEAAERAI111EKMNGMLLND121RKVFVGRFKS131RKEREAELGA141RAKEFTNVYI
151-200151KNFGEDMDDE161RLKDLFGKFG171PALSVKVMTD181ESGKSKGFGF191VSFERHEDAQ
201-250201KAVDEMNGKE211LNGKQIYVGR221AQKKVERQTE231LKRKFEQMKQ241DRITRYQGVN
251-300251LYVKNLDDGI261DDERLRKEFS271PFGTITSAKV281MMEGGRSKGF291GFVCFSSPEE
301-350301ATKAVTEMNG311RIVATKPLYV321ALAQRKEERQ331AHLTNQYMQR341MASVRAVPNP
351-400351VINPYQPAPP361SGYFMAAIPQ371TQNRAAYYPP381SQIAQLRPSP391RWTAQGARPH
401-450401PFQNMPGAIR411PAAPRPPFST421MRPASSQVPR431VMSTQRVANT441STQTMGPRPA
451-500451AAAAAATPAV461RTVPQYKYAA471GVRNPQQHLN481AQPQVTMQQP491AVHVQGQEPL
501-550501TASMLASAPP511QEQKQMLGER521LFPLIQAMHP531TLAGKITGML541LEIDNSELLH
551-591551MLESPESLRS561KVDEAVAVLQ571AHQAKEAAQK581AVNSATGVPT591V
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 83 | SWISSPALM DBPTM CYSMODDB | RNA recognition motif | - |
Unknown
(32651440)
|
GPS-Palm: 0.79
Deep-Palm: 0.60
|
| 87 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.12
|
|
| 294 | SWISSPALM DBPTM CYSMODDB | RNA recognition motif | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
LNCaP
Specificity: 1.000
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 43 | C → C | 0.002288 | SNP | Silent | STAD |
| 67 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 83 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 206 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 309 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 455 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 518 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 518 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 604 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |