Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7ERJ7 | PABPC1 | Polyadenylate-binding protein (PABP) | Homo sapiens (Human) | 604 aa |
Protein Details: E7ERJ7 (PABPC1)
Protein Information
| Accession | E7ERJ7 |
|---|---|
| Protein Names | Polyadenylate-binding protein (PABP) |
| Gene Symbol | PABPC1 |
| Organism | Homo sapiens (Human) |
| Length | 604 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MNPSAPSYPM11ASLYVGDLHP21DVTEAMLYEK31FSPAGPILSI41RVCRDMITRR
51-10051SLGYAYVNFQ61QPADAERALD71TMNFDVIKGK81PVRIMWSQRD91PSLRKSGVVC
101-150101DENGSKGYGF111VHFETQEAAE121RAIEKMNGML131LNDRKVFVGR141FKSRKEREAE
151-200151LGARAKEFTN161VYIKNFGEDM171DDERLKDLFG181KFGPALSVKV191MTDESGKSKG
201-250201FGFVSFERHE211DAQKAVDEMN221GKELNGKQIY231VGRAQKKVER241QTELKRKFEQ
251-300251MKQDRITRYQ261GVNLYVKNLD271DGIDDERLRK281EFSPFGTITS291AKVMMEGGRS
301-350301KGFGFVCFSS311PEEATKAVTE321MNGRIVATKP331LYVALAQRKE341ERQAHLTNQY
351-400351MQRMASVRAV361PNPVINPYQP371APPSGYFMAA381IPQTQNRAAY391YPPSQIAQLR
401-450401PSPRWTAQGA411RPHPFQNMPG421AIRPAAPRPP431FSTMRPASSQ441VPRVMSTQRV
451-500451ANTSTQTMGP461RPAAAAAAAT471PAVRTVPQYK481YAAGVRNPQQ491HLNAQPQVTM
501-550501QQPAVHVQGQ511EPLTASMLAS521APPQEQKQML531GERLFPLIQA541MHPTLAGKIT
551-600551GMLLEIDNSE561LLHMLESPES571LRSKVDEAVA581VLQAHQAKEA591AQKAVNSATG
601-604601VPTV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 43 | RNA BINDING PROTEIN Nucleotide-binding alpha-beta plait domain superfamily RNA-binding domain superfamily RNA recognition motif domain | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.85
|
|
| 100 | - | - | - |
Deep-Palm: 0.35
|
|
| 307 | SWISSPALM DBPTM CYSMODDB | RNA recognition motif | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
LNCaP
Specificity: 0.750
3/3 (100.0%)
1
U937 cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 43 | C → C | 0.002288 | SNP | Silent | STAD |
| 67 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 83 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 206 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 309 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 455 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 518 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 518 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 604 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |