Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7ET17 | HSD17B4 | 17-beta-hydroxysteroid dehydrogenase 4 (D-bifunctional protein) … | Homo sapiens (Human) | 599 aa |
Protein Details: E7ET17 (HSD17B4)
Protein Information
| Accession | E7ET17 |
|---|---|
| Protein Names | 17-beta-hydroxysteroid dehydrogenase 4 (D-bifunctional protein) (Multifunctional protein 2) |
| Gene Symbol | HSD17B4 |
| Organism | Homo sapiens (Human) |
| Length | 599 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.956
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
43
LNCaP cells
Specificity: 0.956
43/46 (93.5%)
2
PC3 cells
Specificity: 0.044
2/4 (50.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MKKQKYGRII11MTSSASGIYG21NFGQANYSAA31KLGLLGLANS41LAIEGRKSNI
51-10051HCNTIAPNAG61SRMTQTVMPE71DLVEALKPEY81VAPLVLWLCH91ESCEENGGLF
101-150101EVGAGWIGKL111RWERTLGAIV121RQKNHPMTPE131AVKANWKKIC141DFENASKPQS
151-200151IQESTGSIIE161VLSKIDSEGG171VSANHTSRAT181STATSGFAGA191IGQKLPPFSY
201-250201AYTELEAIMY211ALGVGASIKD221PKDLKFIYEG231SSDFSCLPTF241GVIIGQKSMM
251-300251GGGLAEIPGL261SINFAKVLHG271EQYLELYKPL281PRAGKLKCEA291VVADVLDKGS
301-350301GVVIIMDVYS311YSEKELICHN321QFSLFLVGSG331GFGGKRTSDK341VKVAVAIPNR
351-400351PPDAVLTDTT361SLNQAALYRL371SGDWNPLHID381PNFASLAGFD391KPILHGLCTF
401-450401GFSARRVLQQ411FADNDVSRFK421AIKARFAKPV431YPGQTLQTEM441WKEGNRIHFQ
451-500451TKVQETGDIV461ISNAYVDLAP471TSGTSAKTPS481EGGKLQSTFV491FEEIGRRLKD
501-550501IGPEVVKKVN511AVFEWHITKG521GNIGAKWTID531LKSGSGKVYQ541GPAKGAADTT
551-599551IILSDEDFME561VVLGKLDPQK571AFFSGRLKAR581GNIMLSQKLQ591MILKDYAKL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 52 | Prediction (Medium) | - | - |
| 140 | Prediction (Low) | - | - |
| 288 | Prediction (Medium) | - | - |
| 398 | Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 226 | C → Y | 0.005435 | SNP | Missense Mutation | ESCA |
| 248 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 385 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 543 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 619 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 633 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 634 | R → C | 0.002506 | SNP | Missense Mutation | COAD |