Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7ET17 | HSD17B4 | 17-beta-hydroxysteroid dehydrogenase 4 (D-bifunctional protein) … | Homo sapiens (Human) | 599 aa |
Protein Details: E7ET17 (HSD17B4)
Protein Information
| Accession | E7ET17 |
|---|---|
| Protein Names | 17-beta-hydroxysteroid dehydrogenase 4 (D-bifunctional protein) (Multifunctional protein 2) |
| Gene Symbol | HSD17B4 |
| Organism | Homo sapiens (Human) |
| Length | 599 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKKQKYGRII11MTSSASGIYG21NFGQANYSAA31KLGLLGLANS41LAIEGRKSNI
51-10051HCNTIAPNAG61SRMTQTVMPE71DLVEALKPEY81VAPLVLWLCH91ESCEENGGLF
101-150101EVGAGWIGKL111RWERTLGAIV121RQKNHPMTPE131AVKANWKKIC141DFENASKPQS
151-200151IQESTGSIIE161VLSKIDSEGG171VSANHTSRAT181STATSGFAGA191IGQKLPPFSY
201-250201AYTELEAIMY211ALGVGASIKD221PKDLKFIYEG231SSDFSCLPTF241GVIIGQKSMM
251-300251GGGLAEIPGL261SINFAKVLHG271EQYLELYKPL281PRAGKLKCEA291VVADVLDKGS
301-350301GVVIIMDVYS311YSEKELICHN321QFSLFLVGSG331GFGGKRTSDK341VKVAVAIPNR
351-400351PPDAVLTDTT361SLNQAALYRL371SGDWNPLHID381PNFASLAGFD391KPILHGLCTF
401-450401GFSARRVLQQ411FADNDVSRFK421AIKARFAKPV431YPGQTLQTEM441WKEGNRIHFQ
451-500451TKVQETGDIV461ISNAYVDLAP471TSGTSAKTPS481EGGKLQSTFV491FEEIGRRLKD
501-550501IGPEVVKKVN511AVFEWHITKG521GNIGAKWTID531LKSGSGKVYQ541GPAKGAADTT
551-599551IILSDEDFME561VVLGKLDPQK571AFFSGRLKAR581GNIMLSQKLQ591MILKDYAKL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 52 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.94
|
|
| 89 | - | - | - |
Deep-Palm: 0.98
|
|
| 93 | - | - | - |
Deep-Palm: 0.95
|
|
| 140 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.77
Deep-Palm: 0.60
|
|
| 236 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.71
|
|
| 288 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.81
Deep-Palm: 0.98
|
|
| 318 | - | - | - |
Deep-Palm: 0.30
|
|
| 398 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
LNCaP
Specificity: 0.364
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.273
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 226 | C → Y | 0.005435 | SNP | Missense Mutation | ESCA |
| 248 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 385 | S → C | 0.003460 | SNP | Missense Mutation | CESC |
| 543 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 619 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 633 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 634 | R → C | 0.002506 | SNP | Missense Mutation | COAD |