Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7ET49 | DAGLB | Diacylglycerol lipase-beta (EC 3.1.1.116) (EC … | Homo sapiens (Human) | 631 aa |
Protein Details: E7ET49 (DAGLB)
Protein Information
| Accession | E7ET49 |
|---|---|
| Protein Names | Diacylglycerol lipase-beta (EC 3.1.1.116) (EC 3.1.1.3) (PUFA-specific triacylglycerol lipase) (Sn1-specific diacylglycerol lipase beta) |
| Gene Symbol | DAGLB |
| Organism | Homo sapiens (Human) |
| Length | 631 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 29575903 31251020 31382980 32651440 32944167 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.718
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
28
LNCaP cells
Specificity: 0.718
28/46 (60.9%)
3
PC3 cells
Specificity: 0.077
3/4 (75.0%)
3
Cerebral cortex
Specificity: 0.077
3/4 (75.0%)
2
DU145 cells
Specificity: 0.051
2/2 (100.0%)
1
Jurkat T cells
Specificity: 0.026
1/25 (4.0%)
1
U937 cells
Specificity: 0.026
1/1 (100.0%)
1
HeLa cells
Specificity: 0.026
1/1 (100.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MHRGKLDCAG11GALLSSYLIV21LMILLAVVIC31TVSAIMCVSM41RGTICNPGPR
51-10051KSMSKLLYIR61LALFFPEMVW71ASLGAAWVAD81GVQCDRTVVN91GIIATVVVSW
101-150101IIIAATVVSI111IIVFDPLGGK121MAPYSSAGPS131HLDSHDSSQL141LNGLKTAATS
151-200151VWETRIKLLC161CCIGKDDHTR171VAFSSTAELF181STYFSDTDLV191PSDIAAGLAL
201-250201LHQQQDNIRN211NQEPAQVVCH221APGSSQEADL231DAELENCHHY241MQFAAAAYGW
251-300251PLYIYRNPLT261GLCRIGGDCC271RSRTTDYDLV281GGDQLNCHFG291SILHTTGLQY
301-350301RDFIHVSFHD311KVYELPFLVA321LDHRKESVVV331AVRGTMSLQD341VLTDLSAESE
351-400351VLDVECEVQD361RLAHKGISQA371ARYVYQRLIN381DGILSQAFSI391APEYRLVIVG
401-450401HSLGGGAAAL411LATMLRAAYP421QVRCYAFSPP431RGLWSKALQE441YSQSFIVSLV
451-500451LGKDVIPRLS461VTNLEDLKRR471ILRVVAHCNK481PKYKILLHGL491WYELFGGNPN
501-550501NLPTELDGGD511QEVLTQPLLG521EQSLLTRWSP531AYSFSSDSPL541DSSPKYPPLY
551-600551PPGRIIHLQE561EGASGRFGCC571SAAHYSAKWS581HEAEFSKILI591GPKMLTDHMP
601-631601DILMRALDSV611VSDRAACVSC621PAQGVSSVDV631A
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 8 | Prediction (High) | - | - |
| 45 | Prediction (High) | - | - |
| 160 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
| 161 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
| 162 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
| 263 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
| 269 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
| 270 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
| 424 | Prediction (Medium) | - | - |
| 478 | Prediction (High) | - | - |
| 569 | CYSMODDB SWISSPALM DBPTM | - | - |
| 570 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | - | - |
| 617 | Prediction (Low) | - | - |
| 620 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 125 | C → C | 0.002288 | SNP | Silent | STAD |
| 125 | C → C | 0.001887 | SNP | Silent | UCEC |
| 191 | S → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 201 | C → C | 0.002020 | SNP | Silent | PRAD |
| 278 | C → C | 0.001887 | SNP | Silent | UCEC |
| 616 | Y → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 658 | C → C | 0.002506 | SNP | Silent | COAD |