Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7EUT5 | GAPDH | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) … | Homo sapiens (Human) | 260 aa |
Protein Details: E7EUT5 (GAPDH)
Protein Information
| Accession | E7EUT5 |
|---|---|
| Protein Names | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (EC 1.2.1.12) (Peptidyl-cysteine S-nitrosylase GAPDH) |
| Gene Symbol | GAPDH |
| Organism | Homo sapiens (Human) |
| Length | 260 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEEMRDPSKI11KWGDAGAEYV21VESTGVFTTM31EKAGAHLQGG41AKRVIISAPS
51-10051ADAPMFVMGV61NHEKYDNSLK71IISNASCTTN81CLAPLAKVIH91DNFGIVEGLM
101-150101TTVHAITATQ111KTVDGPSGKL121WRDGRGALQN131IIPASTGAAK141AVGKVIPELN
151-200151GKLTGMAFRV161PTANVSVVDL171TCRLEKPAKY181DDIKKVVKQA191SEGPLKGILG
201-250201YTEHQVVSSD211FNSDTHSSTF221DAGAGIALND231HFVKLISWYD241NEFGYSNRVV
251-260251DLMAHMASKE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 77 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.94
Deep-Palm: 0.58
|
| 81 | SWISSPALM DBPTM CYSMODDB | Glyceraldehyde 3-phosphate dehydrogenase C-terminal domain |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.81
Deep-Palm: 0.84
|
| 172 | SWISSPALM DBPTM CYSMODDB | Glyceraldehyde 3-phosphate dehydrogenase C-terminal domain |
HeLa
(29575903)
|
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.85
Deep-Palm: 0.95
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.250
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.250
4/4 (100.0%)
3
LNCaP
Specificity: 0.188
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.250
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.062
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 16 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |