Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E7EV01 | CAPN5 | Calpain-5 | Homo sapiens (Human) | 680 aa |
Protein Details: E7EV01 (CAPN5)
Protein Information
| Accession | E7EV01 |
|---|---|
| Protein Names | Calpain-5 |
| Gene Symbol | CAPN5 |
| Organism | Homo sapiens (Human) |
| Length | 680 aa |
| Isoforms | No isoforms |
| Related PMIDs | 22496122 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFSCVKPYED11QNYSALRRDC21RRRKVLFEDP31LFPATDDSLY41YKGTPGPAVR
51-10051WKRPKYSGHS61LAPHRPGWGD71ARRMENVPRP81GSSGCPSSSL91RARDLGICED
101-150101PRLFVDGISS111HDLHQGQVGN121CWFVAACSSL131ASRESLWQKV141IPDWKEQEWD
151-200151PEKPNAYAGI161FHFHFWRFGE171WVDVVIDDRL181PTVNNQLIYC191HSNSRNEFWC
201-250201ALVEKAYAKL211AGCYQALDGG221NTADALVDFT231GGVSEPIDLT241EGDFANDETK
251-300251RNQLFERMLK261VHSRGGLISA271SIKAVTAADM281EARLACGLVK291GHAYAVTDVR
301-350301KVRLGHGLLA311FFKSEKLDMI321RLRNPWGERE331WNGPWSDTSE341EWQKVSKSER
351-400351EKMGVTVQDD361GEFWMTFEDV371CRYFTDIIKC381RVINTSHLSI391HKTWEEARLH
401-450401GAWTLHEDPR411QNRGGGCINH421KDTFFQNPQY431IFEVKKPEDE441VLICIQQRPK
451-500451RSTRREGKGE461NLAIGFDIYK471VEENRQYRMH481SLQHKAASSI491YINSRSVFLR
501-550501TDQPEGRYVI511IPTTFEPGHT521GEFLLRVFTD531VPSNCRELRL541DEPPHTCWSS
551-600551LCGYPQLVTQ561VHVLGAAGLK571DSPTGANSYV581IIKCEGDKVR591SAVQKGTSTP
601-650601EYNVKGIFYR611KKLSQPITVQ621VWNHRVLKDE631FLGQVHLKAD641PDNLQALHTL
651-680651HLRDRNSRQP661SNLPGTVAVH671ILSSTSLMAV
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 4 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.01
|
|
| 20 | Papain-like cysteine peptidase superfamily | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.81
|
|
| 85 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.94
|
|
| 98 | - | - | - |
GPS-Palm: 0.71
Deep-Palm: 0.95
|
|
| 121 | - | - | - |
Deep-Palm: 0.19
|
|
| 127 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.22
|
|
| 190 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
Deep-Palm: 0.26
|
|
| 200 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
Deep-Palm: 0.30
|
|
| 213 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.94
|
|
| 286 | - | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.92
|
|
| 371 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.02
|
|
| 380 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.06
|
|
| 417 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.11
|
|
| 444 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.92
Deep-Palm: 0.87
|
|
| 535 | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.80
|
|
| 547 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.54
|
|
| 552 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.80
|
|
| 584 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.83
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.444
4
LNCaP
Specificity: 0.267
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.267
4/4 (100.0%)
1
EC cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
2
LNCaP cells (Mass)
Specificity: 0.133
2/4 (50.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 254 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 263 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 267 | G → C | 0.002545 | SNP | Missense Mutation | GBM |
| 283 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 286 | W → C | 0.003460 | SNP | Missense Mutation | CESC |
| 373 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 419 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 467 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 499 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 570 | R → C | 0.005618 | SNP | Missense Mutation | PAAD |