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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
E7EVS6 ACTB Actin beta Homo sapiens (Human) 334 aa

Protein Details: E7EVS6 (ACTB)

Protein Information
AccessionE7EVS6
Protein NamesActin beta
Gene SymbolACTB
OrganismHomo sapiens (Human)
Length334 aa
IsoformsNo isoforms
Related PMIDs 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MDDDIAALVV11DNGSGMCKAG21FAGDDAPRAV31FPSIVGRPRH41QGVMVGMGQK
51-10051DSYVGDEAQS61KRGILTLKYP71IEHGIVTNWD81DMEKIWHHTF91YNELRVAPEE
101-150101HPVLLTEAPL111NPKANREKMT121QIMFETFNTP131AMYVAIQAVL141SLYASGRTTG
151-200151IVMDSGDGVT161HTVPIYEGYA171LPHAILRLDL181AGRDLTDYLM191KILTERGYSF
201-250201TTTAEREIVR211DIKEKLCYVA221LDFEQEMATA231ASSSSLEKSY241ELPDGQVITI
251-300251GNERFRCPEA261LFQPSFLGME271SCGIHETTFN281SIMKCDVDIR291KDLYANTVLS
301-334301GGTTMYPGIA311DRMQKEITAL321APSTMKIKVG331VFPA
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
17 SWISSPALM DBPTM CYSMODDB Actin ATPase, nucleotide binding domain Actin family
HeLa (29575903)
cerebral cortex (36430497)
LNCaP (31251020)
Unknown (32651440)
Deep-Palm: 0.93
217 - -
cerebral cortex (36430497)
Unknown (32651440)
GPS-Palm: 0.68
Deep-Palm: 0.94
257 - -
cerebral cortex (36430497)
LNCaP (31251020)
Unknown (32651440)
Deep-Palm: 0.69
272 - -
cerebral cortex (36430497)
LNCaP (31251020)
Unknown (32651440)
Deep-Palm: 0.14
285 - -
Unknown (32651440)
Deep-Palm: 0.18
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
cerebral cortex
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.667
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.167
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
69 Y → C 0.001764 SNP Missense Mutation LUAD
86 W → C 0.027027 SNP Missense Mutation DLBC
91 Y → C 0.001764 SNP Missense Mutation LUAD
156 G → C 0.002545 SNP Missense Mutation GBM
177 R → C 0.002020 SNP Missense Mutation PRAD
177 R → C 0.001887 SNP Missense Mutation UCEC
196 R → C 0.002288 SNP Missense Mutation STAD
196 R → C 0.002427 SNP Missense Mutation BLCA
210 R → C 0.001887 SNP Missense Mutation UCEC
217 C → Y 0.027027 SNP Missense Mutation DLBC
217 C → C 0.001969 SNP Silent LGG
240 Y → C 0.001764 SNP Missense Mutation LUAD
265 S → C 0.002141 SNP Missense Mutation SKCM
279 F → C 0.002545 SNP Missense Mutation GBM
281 S → C 0.002427 SNP Missense Mutation BLCA
294 Y → C 0.002288 SNP Missense Mutation STAD
335 R → C 0.003774 SNP Missense Mutation UCEC
372 R → C 0.002506 SNP Missense Mutation COAD