Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PBS1 | PAICS | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase … | Homo sapiens (Human) | 413 aa |
Protein Details: E9PBS1 (PAICS)
Protein Information
| Accession | E9PBS1 |
|---|---|
| Protein Names | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 4.1.1.21) (EC 6.3.2.6) |
| Gene Symbol | PAICS |
| Organism | Homo sapiens (Human) |
| Length | 413 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 31251020 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.821
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
23
LNCaP cells
Specificity: 0.821
23/46 (50.0%)
3
PC3 cells
Specificity: 0.107
3/4 (75.0%)
2
Jurkat T cells
Specificity: 0.071
2/25 (8.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MATAEVLNIG11KKLYEGKTKE21VYELLDSPGK31VLLQSKDQIT41AGNAARKNHL
51-10051EGKAAISNKI61TSCIFQLLQE71AGIKTAFTRK81CGETAFIAPQ91CEMIPIEWVC
101-150101RRIATGSFLK111RNPGVKEGYK121FYPPKVELFF131KDDANNDPQW141SEEQLIAAKF
151-200151CFAGLLIGQT161EVDIMSHATQ171AIFEILEKSW181LPQNCTLVDM191KIEFGVDVTT
201-250201KEIVLADVID211NDSWRLWPSG221DRSQQKDKQS231YRDLKEVTPE241GLQMVKKNFE
251-300251WVAERVELLL261KSESQCRVVV271LMGSTSDLGH281CEKIKKACGN291FGIPCELRVT
301-350301SAHKGPDETL311RIKAEYEGDG321IPTVFVAVAG331RSNGLGPVMS341GNTAYPVISC
351-400351PPLTPDWGVQ361DVWSSLRLPS371GLGCSTVLSP381EGSAQFAAQI391FGLSNHLVWS
401-413401KLRASILNTW411ISL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 63 | Experimental CYSMODDB SWISSPALM DBPTM Prediction (Medium) | SAICAR synthetase | 29575903 |
| 81 | Prediction (Low) | - | - |
| 100 | Prediction (Medium) | - | - |
| 151 | Prediction (Medium) | - | - |
| 185 | Prediction (Medium) | - | - |
| 281 | Prediction (Medium) | - | - |
| 288 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | AIR carboxylase | - |
| 295 | CYSMODDB SWISSPALM DBPTM Prediction (Medium) | AIR carboxylase | - |
| 374 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 185 | C → C | 0.001887 | SNP | Silent | UCEC |