Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PBS1 | PAICS | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase … | Homo sapiens (Human) | 413 aa |
Protein Details: E9PBS1 (PAICS)
Protein Information
| Accession | E9PBS1 |
|---|---|
| Protein Names | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 4.1.1.21) (EC 6.3.2.6) |
| Gene Symbol | PAICS |
| Organism | Homo sapiens (Human) |
| Length | 413 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATAEVLNIG11KKLYEGKTKE21VYELLDSPGK31VLLQSKDQIT41AGNAARKNHL
51-10051EGKAAISNKI61TSCIFQLLQE71AGIKTAFTRK81CGETAFIAPQ91CEMIPIEWVC
101-150101RRIATGSFLK111RNPGVKEGYK121FYPPKVELFF131KDDANNDPQW141SEEQLIAAKF
151-200151CFAGLLIGQT161EVDIMSHATQ171AIFEILEKSW181LPQNCTLVDM191KIEFGVDVTT
201-250201KEIVLADVID211NDSWRLWPSG221DRSQQKDKQS231YRDLKEVTPE241GLQMVKKNFE
251-300251WVAERVELLL261KSESQCRVVV271LMGSTSDLGH281CEKIKKACGN291FGIPCELRVT
301-350301SAHKGPDETL311RIKAEYEGDG321IPTVFVAVAG331RSNGLGPVMS341GNTAYPVISC
351-400351PPLTPDWGVQ361DVWSSLRLPS371GLGCSTVLSP381EGSAQFAAQI391FGLSNHLVWS
401-413401KLRASILNTW411ISL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 63 | SWISSPALM DBPTM CYSMODDB | SAICAR synthetase |
HeLa
(29575903)
|
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.95
|
| 81 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.93
|
|
| 91 | - | - | - |
Deep-Palm: 0.44
|
|
| 100 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.33
|
|
| 151 | - | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.56
|
|
| 185 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.53
|
|
| 266 | - | - | - |
Deep-Palm: 0.96
|
|
| 281 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.87
|
|
| 288 | SWISSPALM DBPTM CYSMODDB | AIR carboxylase | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.93
|
| 295 | SWISSPALM DBPTM CYSMODDB | AIR carboxylase | - | - |
GPS-Palm: 0.79
Deep-Palm: 0.96
|
| 350 | - | - | - |
Deep-Palm: 0.48
|
|
| 374 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.88
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.333
4/4 (100.0%)
3
PC3
Specificity: 0.250
3/3 (100.0%)
1
LNCaP
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.333
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 185 | C → C | 0.001887 | SNP | Silent | UCEC |