Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PC15 | AGK | Acylglycerol kinase, mitochondrial (EC 2.7.1.107) … | Homo sapiens (Human) | 394 aa |
Protein Details: E9PC15 (AGK)
Protein Information
| Accession | E9PC15 |
|---|---|
| Protein Names | Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) |
| Gene Symbol | AGK |
| Organism | Homo sapiens (Human) |
| Length | 394 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 31251020 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MENTDSDNLL11RRAACQEAQV21FGNQLIPPNA31QVKKATVFLN41PAACKGKART
51-10051LFEKNAAPIL61HLSGMDVTIV71KTDYEGQAKK81LLELMENTDV91IIVAGGDGTL
101-150101QEVVTGVLRR111TDEATFSKIP121IGFIPLGETS131SLSHTLFAES141GNKVQHITDA
151-200151TLAIVKGETV161PLDVLQIKGE171KEQPVFAMTG181LRWGSFRDAG191VKVSKYWYLG
201-250201PLKIKAAHFF211STLKEWPQTH221QASISYTGPT231ERPPNEPEET241PVQRPSLYRR
251-300251ILRRLASYWA261QPQDALSQEV271SPEVWKDVQL281STIELSITTR291NNQLDPTSKE
301-350301DFLNICIEPD311TISKGDFITI321GSRKVRNPKL331HVEGTECLQA341SQCTLLIPEG
351-394351AGGSFSIDSE361EYEAMPVEVK371LLPRKLQFFC381DPRKREQMLT391SPTQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 15 | - | - | - |
Deep-Palm: 0.72
|
|
| 44 | Inorganic polyphosphate/ATP-NAD kinase, N-terminal Diacylglycerol kinase, catalytic domain | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 306 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.50
|
|
| 337 | - | - | - |
Deep-Palm: 0.95
|
|
| 343 | - | - | - |
Deep-Palm: 0.95
|
|
| 380 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.91
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.429
3/3 (100.0%)
2
PC3
Specificity: 0.286
2/2 (100.0%)
1
frontal cortex
Specificity: 0.143
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.143
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 197 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 224 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 244 | W → C | 0.004219 | SNP | Missense Mutation | SARC |
| 365 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |