Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PDE8 | HSPA4L | Heat shock 70 kDa protein … | Homo sapiens (Human) | 813 aa |
Protein Details: E9PDE8 (HSPA4L)
Protein Information
| Accession | E9PDE8 |
|---|---|
| Protein Names | Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Osmotic stress protein 94) |
| Gene Symbol | HSPA4L |
| Organism | Homo sapiens (Human) |
| Length | 813 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MKPILLFMER11ACISLGSRTR21AIGNAAKSQI31VTNVRNTIHG41FKKLHGRSFD
51-10051DPIVQTERIR61LPYELQKMPN71GSAGVKVRYL81EEERPFAIEQ91VTGMLLAKLK
101-150101ETSENALKKP111VADCVISIPS121FFTDAERRSV131MAAAQVAGLN141CLRLMNETTA
151-200151VALAYGIYKQ161DLPPLDEKPR171NVVFIDMGHS181AYQVLVCAFN191KGKLKVLATT
201-250201FDPYLGGRNF211DEALVDYFCD221EFKTKYKINV231KENSRALLRL241YQECEKLKKL
251-300251MSANASDLPL261NIECFMNDLD271VSSKMNRAQF281EQLCASLLAR291VEPPLKAVME
301-350301QANLQREDIS311SIEIVGGATR321IPAVKEQITK331FFLKDISTTL341NADEAVARGC
351-400351ALQCAILSPA361FKVREFSITD371LVPYSITLRW381KTSFEDGSGE391CEVFCKNHPA
401-450401PFSKVITFHK411KEPFELEAFY421TNLHEVPYPD431ARIGSFTIQN441VFPQSDGDSS
451-500451KVKVKVRVNI461HGIFSVASAS471VIEKQNLEGD481HSDAPMETET491SFKNENKDNM
501-550501DKMQVDQEEG511HQKCHAEHTP521EEEIDHTGAK531TKSAVSDKQD541RLNQTLKKGK
551-600551VKSIDLPIQS561SLCRQLGQDL571LNSYIENEGK581MIMQDKLEKE591RNDAKNAVEE
601-650601YVYDFRDRLG611TVYEKFITPE621DLSKLSAVLE631DTENWLYEDG641EDQPKQVYVD
651-700651KLQELKKYGQ661PIQMKYMEHE671ERPKALNDLG681KKIQLVMKVI691EAYRNKDERY
701-750701DHLDPTEMEK711VEKCISDAMS721WLNSKMNAQN731KLSLTQDPVV741KVSEIVAKSK
751-800751ELDNFCNPII761YKPKPKAEVP771EDKPKANSEH781NGPMDGQSGT791ETKSDSTKDS
801-813801SQHTKSSGEM811EVD
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 12 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.33
|
|
| 114 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.94
|
|
| 141 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 187 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.95
|
|
| 219 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.56
|
|
| 244 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.97
|
|
| 264 | - | - | - |
Deep-Palm: 0.57
|
|
| 284 | - | - | - |
GPS-Palm: 0.90
Deep-Palm: 0.98
|
|
| 350 | SWISSPALM DBPTM CYSMODDB | Hsp70 protein |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.77
Deep-Palm: 0.84
|
| 354 | SWISSPALM DBPTM CYSMODDB | Hsp70 protein | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.85
Deep-Palm: 0.83
|
| 391 | - | - | - |
Deep-Palm: 0.33
|
|
| 395 | - | - | - |
Deep-Palm: 0.09
|
|
| 514 | - | - | - |
Deep-Palm: 0.03
|
|
| 563 | - | - | - |
GPS-Palm: 0.89
Deep-Palm: 0.92
|
|
| 714 | - | - | - |
Deep-Palm: 0.23
|
|
| 756 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.600
3
cerebral cortex
Specificity: 0.333
3/3 (100.0%)
2
LNCaP
Specificity: 0.222
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.444
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 14 | Y → C | 0.007299 | SNP | Missense Mutation | READ |
| 428 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 483 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 483 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 483 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 483 | R → C | 0.011321 | SNP | Missense Mutation | UCEC |
| 518 | F → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 740 | C → R | 0.002427 | SNP | Missense Mutation | BLCA |