Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PDF2 | OGDH | 2-oxoglutarate dehydrogenase complex component E1 … | Homo sapiens (Human) | 1034 aa |
Protein Details: E9PDF2 (OGDH)
Protein Information
| Accession | E9PDF2 |
|---|---|
| Protein Names | 2-oxoglutarate dehydrogenase complex component E1 (EC 1.2.4.2) (2-oxoglutarate dehydrogenase, mitochondrial) (Alpha-ketoglutarate dehydrogenase) (Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase) |
| Gene Symbol | OGDH |
| Organism | Homo sapiens (Human) |
| Length | 1034 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFHLRTCAAK11LRPLTASQTV21KTFSQNRPAA31ARTFQQIRCY41SAPVAAEPFL
51-10051SGTSSNYVEE61MYCAWLENPK71SVHKSWDIFF81RNTNAGAPPG91TAYQSPLPLS
101-150101RGSLAAVAHA111QSLVEAQPNV121DKLVEDHLAV131QSLIRAYQVR141GHHIAKLDPL
151-200151GISCVNFDDA161PVTVSSNVDL171AVFKERLRML181TVGGFYGLDE191SDLDKVFHLP
201-250201TTTFIGGQES211ALPLREIIRR221LEMAYCQHIG231VEFMFINDLE241QCQWIRQKFE
251-300251TPGIMQFTNE261EKRTLLARLV271RSTRFEEFLQ281RKWSSEKRFG291LEGCEVLIPA
301-350301LKTIIDKSSE311NGVDYVIMGM321PHRGRLNVLA331NVIRKELEQI341FCQFDSKLEA
351-400351ADEGSGDVKY361HLGMYHRRIN371RVTDRNITLS381LVANPSHLEA391ADPVVMGKTK
401-450401AEQFYCGDTE411GKKVMSILLH421GDAAFAGQGI431VYETFHLSDL441PSYTTHGTVH
451-500451VVVNNQIGFT461TDPRMARSSP471YPTDVARVVN481APIFHVNSDD491PEAVMYVCKV
501-550501AAEWRSTFHK511DVVVDLVCYR521RNGHNEMDEP531MFTQPLMYKQ541IRKQKPVLQK
551-600551YAELLVSQGV561VNQPEYEEEI571SKYDKICEEA581FARSKDEKIL591HIKHWLDSPW
601-650601PGFFTLDGQP611RSMSCPSTGL621TEDILTHIGN631VASSVPVENF641TIHGGLSRIL
651-700651KTRGEMVKNR661TVDWALAEYM671AFGSLLKEGI681HIRLSGQDVE691RGTFSHRHHV
701-750701LHDQNVDKRT711CIPMNHLWPN721QAPYTVCNSS731LSEYGVLGFE741LGFAMASPNA
751-800751LVLWEAQFGD761FHNTAQCIID771QFICPGQAKW781VRQNGIVLLL791PHGMEGMGPE
801-850801HSSARPERFL811QMCNDDPDVL821PDLKEANFDI831NQLYDCNWVV841VNCSTPGNFF
851-900851HVLRRQILLP861FRKPLIIFTP871KSLLRHPEAR881SSFDEMLPGT891HFQRVIPEDG
901-950901PAAQNPENVK911RLLFCTGKVY921YDLTRERKAR931DMVGQVAITR941IEQLSPFPFD
951-1000951LLLKEVQKYP961NAELAWCQEE971HKNQGYYDYV981KPRLRTTISR991AKPVWYAGRD
1001-10341001PAAAPATGNK1011KTHLTELQRL1021LDTAFDLDVF1031KNFS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 7 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.06
|
|
| 39 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.81
|
|
| 63 | - | - | - |
Deep-Palm: 0.08
|
|
| 154 | - | - | - |
Deep-Palm: 0.78
|
|
| 226 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.70
|
|
| 242 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.05
|
|
| 294 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.91
Deep-Palm: 0.97
|
|
| 342 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.81
Deep-Palm: 0.94
|
|
| 406 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.69
Deep-Palm: 0.91
|
|
| 498 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.11
|
|
| 518 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.87
Deep-Palm: 0.38
|
|
| 577 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.84
Deep-Palm: 0.61
|
|
| 615 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.78
Deep-Palm: 0.77
|
|
| 711 | - | - | - |
Deep-Palm: 0.04
|
|
| 727 | - | - | - |
Deep-Palm: 0.58
|
|
| 767 | - | - | - |
Deep-Palm: 0.11
|
|
| 774 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.11
|
|
| 813 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
Deep-Palm: 0.85
|
|
| 836 | - | - | - |
Deep-Palm: 0.06
|
|
| 843 | - | - | - |
Deep-Palm: 0.09
|
|
| 915 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.96
|
|
| 967 | - | - | - |
Deep-Palm: 0.79
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.500
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.500
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 41 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 81 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 81 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 277 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 283 | C → C | 0.001887 | SNP | Silent | UCEC |
| 604 | C → C | 0.001764 | SNP | Silent | LUAD |
| 653 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 686 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 700 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| 713 | Y → C | 0.002976 | SNP | Missense Mutation | KIRC |
| 769 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 794 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 864 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 904 | C → C | 0.001969 | SNP | Silent | LGG |
| 909 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |