Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PEJ4 | DLAT | Acetyltransferase component of pyruvate dehydrogenase … | Homo sapiens (Human) | 542 aa |
Protein Details: E9PEJ4 (DLAT)
Protein Information
| Accession | E9PEJ4 |
|---|---|
| Protein Names | Acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.12) |
| Gene Symbol | DLAT |
| Organism | Homo sapiens (Human) |
| Length | 542 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 31382980 32651440 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.875
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
42
LNCaP cells
Specificity: 0.875
42/46 (91.3%)
3
PC3 cells
Specificity: 0.062
3/4 (75.0%)
1
Jurkat T cells
Specificity: 0.021
1/25 (4.0%)
1
U937 cells
Specificity: 0.021
1/1 (100.0%)
1
HeLa cells
Specificity: 0.021
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MWRVCARRAQ11NVAPWAGLEA21RWTALQEVPG31TPRVTSRSGP41APARRNSVTT
51-10051GYGGVRALCG61WTPSSGATPR71NRLLLQLLGS81PGRRYYSLPP91HQKVPLPSLS
101-150101PTMQAGTIAR111WEKKEGDKIN121EGDLIAEVET131DKATVGFESL141EECYMAKILV
151-200151AEGTRDVPIG161AIICITVGKP171EDIEAFKNYT181LDSSAAPTPQ191AAPAPTPAAT
201-250201ASPPTPSAQA211PGSSYPPHMQ221VAAVPPTPQP231LAPTPSAPCP241ATPAGPKGRV
251-300251FVSPLAKKLA261VEKGIDLTQV271KGTGPDGRIT281KKDIDSFVPS291KVAPAPAAVV
301-350301PPTGPGMAPV311PTGVFTDIPI321SNIRRVIAQR331LMQSKQTIPH341YYLSIDVNMG
351-400351EVLLVRKELN361KILEGRSKIS371VNDFIIKASA381LACLKVPEAN391SSWMDTVIRQ
401-450401NHVVDVSVAV411STPAGLITPI421VFNAHIKGVE431TIANDVVSLA441TKAREGKLQP
451-500451HEFQGGTFTI461SNLGMFGIKN471FSAIINPPQA481CILAIGASED491KLVPADNEKG
501-542501FDVASMMSVT511LSCDHRVVDG521AVGAQWLAEF531RKYLEKPITM541LL
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 5 | Prediction (High) | - | - |
| 59 | Prediction (Low) | - | - |
| 143 | Prediction (Medium) | - | - |
| 164 | Prediction (High) | - | - |
| 383 | Prediction (High) | - | - |
| 481 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 144 | Y → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 488 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |