Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PFW3 | AP2M1 | AP-2 complex subunit mu | Homo sapiens (Human) | 460 aa |
Protein Details: E9PFW3 (AP2M1)
Protein Information
| Accession | E9PFW3 |
|---|---|
| Protein Names | AP-2 complex subunit mu |
| Gene Symbol | AP2M1 |
| Organism | Homo sapiens (Human) |
| Length | 460 aa |
| Isoforms | No isoforms |
| Related PMIDs | 26876311 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MIGGLFIYNH11KGEVLISRVY21RDDIGSRQAA31DSAVFSSSGP41FPGEWLEANR
51-10051RNAVDAFRVN61VIHARQQVRS71PVTNIARTSF81FHVKRSNIWL91AAVTKQNVNA
101-150101AMVFEFLYKM111CDVMAAYFGK121ISEENIKNNF131VLIYELLDEI141LDFGYPQNSE
151-200151TGALKTFITQ161QGIKSQHQTK171EEQSQITSQV181TGQIGWRREG191IKYRRNELFL
201-250201DVLESVNLLM211SPQGQVLSAH221VSGRVVMKSY231LSGMPECKFG241MNDKIVIEKQ
251-300251GKGTADETSK261SGKQSIAIDD271CTFHQCVRLS281KFDSERSISF291IPPDGEFELM
301-350301RYRTTKDIIL311PFRVIPLVRE321VGRTKLEVKV331VIKSNFKPSL341LAQKIEVRIP
351-400351TPLNTSGVQV361ICMKGKAKYK371ASENAIVWKI381KRMAGMKESQ391ISAEIELLPT
401-450401NDKKKWARPP411ISMNFEVPFA421PSGLKVRYLK431VFEPKLNYSD441HDVIKWVRYI
451-460451GRSGIYETRC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 111 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.12
|
|
| 237 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.44
|
|
| 271 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.58
|
|
| 276 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.32
|
|
| 362 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.93
Deep-Palm: 0.97
|
|
| 460 | - | - | - |
GPS-Palm: 0.95
Deep-Palm: 0.02
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
4
PC3
Specificity: 0.250
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.250
4/4 (100.0%)
3
LNCaP
Specificity: 0.188
3/3 (100.0%)
1
frontal cortex
Specificity: 0.062
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.250
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 44 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 44 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 83 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 246 | C → Y | 0.002747 | SNP | Missense Mutation | LIHC |
| 251 | C → C | 0.002033 | SNP | Silent | LUSC |
| 278 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 298 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 397 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 423 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |