Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PHF7 | MCCC1 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial … | Homo sapiens (Human) | 616 aa |
Protein Details: E9PHF7 (MCCC1)
Protein Information
| Accession | E9PHF7 |
|---|---|
| Protein Names | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) |
| Gene Symbol | MCCC1 |
| Organism | Homo sapiens (Human) |
| Length | 616 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
4
LNCaP cells
Specificity: 1.000
4/46 (8.7%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
PC3 cells
Specificity: 0.000
0/4 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MEKIIQVAKT11SAAQAIHPGC21GFLSENMEFA31ELCKQEGIIF41IGPPPSAIRD
51-10051MGIKSTSKSI61MAAAGVPVVE71GYHGEDQSDQ81CLKEHARRIG91YPVMIKAVRG
101-150101GGGKGMRIVR111SEQEFQEQLE121SARREAKKSF131NDDAMLIEKF141VDTPRHVEVQ
151-200151VFGDHHGNAV161YLFERDCSVQ171RRHQKIIEEA181PAPGIKSEVR191KKLGEAAVRA
201-250201AKAVNYVGAG211TVEFIMDSKH221NFCFMEMNTR231LQVEHPVTEM241ITGTDLVEWQ
251-300251LRIAAGEKIP261LSQEEITLQG271HAFEARIYAE281DPSNNFMPVA291GPLVHLSTPR
301-350301ADPSTRIETG311VRQGDEVSVH321YDPMIAKLVV331WAADRQAALT341KLRYSLRQYN
351-400351IVGLHTNIDF361LLNLSGHPEF371EAGNVHTDFI381PQHHKQLLLS391RKAAAKESLC
401-450401QAALGLILKE411KAMTDTFTLQ421AHDQFSPFSS431SSGRRLNISY441TRNMTLKDGK
451-500451NNVAIAVTYN461HDGSYSMQIE471DKTFQVLGNL481YSEGDCTYLK491CSVNGVASKA
501-550501KLIILENTIY511LFSKEGSIEI521DIPVPKYLSS531VSSQETQGGP541LAPMTGTIEK
551-600551VFVKAGDKVK561AGDSLMVMIA571MKMEHTIKSP581KDGTVKKVFY591REGAQANRHT
601-616601PLVEFEEEES611DKRESE
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 33 | Prediction (Low) | - | - |
| 167 | Prediction (Medium) | - | - |
| 400 | CYSMODDB SWISSPALM DBPTM Prediction (High) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 66 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 107 | Y → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 149 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 200 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 276 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 323 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |