Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PHF7 | MCCC1 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial … | Homo sapiens (Human) | 616 aa |
Protein Details: E9PHF7 (MCCC1)
Protein Information
| Accession | E9PHF7 |
|---|---|
| Protein Names | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) |
| Gene Symbol | MCCC1 |
| Organism | Homo sapiens (Human) |
| Length | 616 aa |
| Isoforms | No isoforms |
| Related PMIDs | No related PMIDs |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEKIIQVAKT11SAAQAIHPGC21GFLSENMEFA31ELCKQEGIIF41IGPPPSAIRD
51-10051MGIKSTSKSI61MAAAGVPVVE71GYHGEDQSDQ81CLKEHARRIG91YPVMIKAVRG
101-150101GGGKGMRIVR111SEQEFQEQLE121SARREAKKSF131NDDAMLIEKF141VDTPRHVEVQ
151-200151VFGDHHGNAV161YLFERDCSVQ171RRHQKIIEEA181PAPGIKSEVR191KKLGEAAVRA
201-250201AKAVNYVGAG211TVEFIMDSKH221NFCFMEMNTR231LQVEHPVTEM241ITGTDLVEWQ
251-300251LRIAAGEKIP261LSQEEITLQG271HAFEARIYAE281DPSNNFMPVA291GPLVHLSTPR
301-350301ADPSTRIETG311VRQGDEVSVH321YDPMIAKLVV331WAADRQAALT341KLRYSLRQYN
351-400351IVGLHTNIDF361LLNLSGHPEF371EAGNVHTDFI381PQHHKQLLLS391RKAAAKESLC
401-450401QAALGLILKE411KAMTDTFTLQ421AHDQFSPFSS431SSGRRLNISY441TRNMTLKDGK
451-500451NNVAIAVTYN461HDGSYSMQIE471DKTFQVLGNL481YSEGDCTYLK491CSVNGVASKA
501-550501KLIILENTIY511LFSKEGSIEI521DIPVPKYLSS531VSSQETQGGP541LAPMTGTIEK
551-600551VFVKAGDKVK561AGDSLMVMIA571MKMEHTIKSP581KDGTVKKVFY591REGAQANRHT
601-616601PLVEFEEEES611DKRESE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 20 | Pre-ATP-grasp domain superfamily Biotin carboxylase-like, N-terminal domain Biotin carboxylation domain Biotin-dependent Carboxylase Complex | - | - |
Deep-Palm: 0.92
|
|
| 33 | Pre-ATP-grasp domain superfamily Biotin-dependent Carboxylase Complex Biotin carboxylation domain Biotin carboxylase-like, N-terminal domain | - | - |
GPS-Palm: 0.65
Deep-Palm: 0.89
|
|
| 81 | - | - | - |
Deep-Palm: 0.89
|
|
| 167 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.59
|
|
| 223 | - | - | - |
Deep-Palm: 0.35
|
|
| 400 | SWISSPALM DBPTM CYSMODDB | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
| 486 | - | - | - |
Deep-Palm: 0.80
|
|
| 491 | - | - | - |
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 66 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 107 | Y → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 149 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 200 | Y → C | 0.003559 | SNP | Missense Mutation | KIRP |
| 276 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 323 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |