Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PHR9 | PLSCR4 | Phospholipid scramblase | Homo sapiens (Human) | 239 aa |
Protein Details: E9PHR9 (PLSCR4)
Protein Information
| Accession | E9PHR9 |
|---|---|
| Protein Names | Phospholipid scramblase |
| Gene Symbol | PLSCR4 |
| Organism | Homo sapiens (Human) |
| Length | 239 aa |
| Isoforms | No isoforms |
| Related PMIDs | 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSGVVPTAPE11QPAGEMENQT21KPPDPRPDAP31PEYNSHFLPG41PPGTAVPPPT
51-10051GYPGGLPMGY61YSPQQPSTFP71LYQPVGGIHP81VRYQPGKYPM91PNQSVPITWM
101-150101PGPTPMANCP111PGLEYLVQLE121VQCPPGVTIG131FVAEHWNLCR141AVYSIQNEKK
151-200151ENVMRVRGPC161STYGCGSDSV171FEVKSLDGIS181NIGSIIRKWN191GLLSAMADAD
201-239201HFDIHFPLDL211DVKMKAMIFG221ACFLIDFMYF231ERSPPQRSR
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 109 | - | - | - |
Deep-Palm: 0.28
|
|
| 123 | - | - | - |
Deep-Palm: 0.69
|
|
| 139 | SWISSPALM DBPTM CYSMODDB | Scramblase |
HeLa
(29575903)
| - |
GPS-Palm: 0.79
Deep-Palm: 0.82
|
| 160 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.71
Deep-Palm: 0.74
|
|
| 165 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.82
|
|
| 222 | - | - | - |
Deep-Palm: 0.40
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
PC3
Specificity: 0.333
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.333
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.333
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 195 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 204 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 247 | R → C | 0.002033 | SNP | Missense Mutation | THCA |
| 247 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 250 | C → S | 0.002033 | SNP | Missense Mutation | LUSC |
| 312 | C → Lfs*5 | 0.002545 | INS | Frame Shift Ins | GBM |
| 327 | R → C | 0.002506 | SNP | Missense Mutation | COAD |