Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PHZ1 | ECE1 | Endothelin-converting enzyme 1 | Homo sapiens (Human) | 134 aa |
Protein Details: E9PHZ1 (ECE1)
Protein Information
| Accession | E9PHZ1 |
|---|---|
| Protein Names | Endothelin-converting enzyme 1 |
| Gene Symbol | ECE1 |
| Organism | Homo sapiens (Human) |
| Length | 134 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 22496122 29575903 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MEQMSTYKRA11TLDEEDLVDS21LSEGDAYPNG31LQVNFHSPRS41GQRCWAARTQ
51-10051VEKRLVVLVV61LLAAGLVACL71AALGIQYQTR81SPSVCLSEAC91VSVTSSILSS
101-134101MDPTVDPCHD111FFSYACGGWI121KANPVPDGHS131RWGT
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 44 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
Deep-Palm: 0.95
|
| 69 | - | - | - |
Deep-Palm: 0.98
|
|
| 85 | - | - | - |
Deep-Palm: 0.90
|
|
| 90 | - | - | - |
Deep-Palm: 0.74
|
|
| 108 | - | - | - |
Deep-Palm: 0.09
|
|
| 116 | - | - | - |
Deep-Palm: 0.11
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
3
LNCaP
Specificity: 0.500
3/3 (100.0%)
1
HeLa cell
Specificity: 0.167
1/1 (100.0%)
1
EC cell
Specificity: 0.167
1/1 (100.0%)
1
DU145 cell
Specificity: 0.167
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 83 | C → Y | 0.002288 | SNP | Missense Mutation | STAD |
| 83 | C → F | 0.002141 | SNP | Missense Mutation | SKCM |
| 104 | C → C | 0.002288 | SNP | Silent | STAD |
| 183 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 208 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 232 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 409 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 509 | F → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 630 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 736 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 767 | C → C | 0.002506 | SNP | Silent | COAD |