Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PKE3 | HSPA8 | Heat shock cognate 71 kDa … | Homo sapiens (Human) | 627 aa |
Protein Details: E9PKE3 (HSPA8)
Protein Information
| Accession | E9PKE3 |
|---|---|
| Protein Names | Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) |
| Gene Symbol | HSPA8 |
| Organism | Homo sapiens (Human) |
| Length | 627 aa |
| Isoforms | No isoforms |
| Related PMIDs | 21076176 29575903 31251020 31382980 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.766
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.766
36/46 (78.3%)
6
Jurkat T cells
Specificity: 0.128
6/25 (24.0%)
4
PC3 cells
Specificity: 0.085
4/4 (100.0%)
1
U937 cells
Specificity: 0.021
1/1 (100.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSKGPAVGID11LGTTYSCVGV21FQHGKVEIIA31NDQGNRTTPS41YVAFTDTERL
51-10051IGDAAKNQVA61MNPTNTVFDA71KRLIGRRFDD81AVVQSDMKHW91PFMVVNDAGR
101-150101PKVQVEYKGE111TKSFYPEEVS121SMVLTKMKEI131AEAYLGKATK141DAGTIAGLNV
151-200151LRIINEPTAA161AIAYGLDKKV171GAERNVLIFD181LGGGTFDVSI191LTIEDGIFEV
201-250201KSTAGDTHLG211GEDFDNRMVN221HFIAEFKRKH231KKDISENKRA241VRRLRTACER
251-300251AKRTLSSSTQ261ASIEIDSLYE271GIDFYTSITR281ARFEELNADL291FRGTLDPVEK
301-350301ALRDAKLDKS311QIHDIVLVGG321STRIPKIQKL331LQDFFNGKEL341NKSINPDEAV
351-400351AYGAAVQAAI361LSGDKSENVQ371DLLLLDVTPL381SLGIETAGGV391MTVLIKRNTT
401-450401IPTKQTQTFT411TYSDNQPGVL421IQVYEGERAM431TKDNNLLGKF441ELTGIPPAPR
451-500451GVPQIEVTFD461IDANGILNVS471AVDKSTGKEN481KITITNDKGR491LSKEDIERMV
501-550501QEAEKYKAED511EKQRDKVSSK521NSLESYAFNM531KATVEDEKLQ541GKINDEDKQK
551-600551ILDKCNEIIN561WLDKNQTAEK571EEFEHQQKEL581EKVCNPIITK591LYQSAGGMPG
601-627601GMPGGFPGGG611APPSGGASSG621PTIEEVD
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 17 | Experimental CYSMODDB SWISSPALM DBPTM | Hsp70 protein | 29575903 |
| 248 | Prediction (High) | - | - |
| 584 | CYSMODDB SWISSPALM DBPTM Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 267 | C → W | 0.002020 | SNP | Missense Mutation | PRAD |
| 311 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 342 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 416 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 580 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |