Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PN11 | RHOC | Ras homolog family member C | Homo sapiens (Human) | 129 aa |
Protein Details: E9PN11 (RHOC)
Protein Information
| Accession | E9PN11 |
|---|---|
| Protein Names | Ras homolog family member C |
| Gene Symbol | RHOC |
| Organism | Homo sapiens (Human) |
| Length | 129 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MVSISGGDLP11TGLDFISAPE21PALSSCSLGT31SAGWSPTMAA41IRKKLVIVGD
51-10051GACGKTCLLI61VFSKDQFPEV71YVPTVFENYI81ADIEVDGKQV91ELALWDTAGQ
101-129101EDYDRLRPLS111YPDTDVILMC121FSIDSPDSL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 26 | - | - | - |
Deep-Palm: 0.94
|
|
| 53 | SWISSPALM DBPTM CYSMODDB | Ras family | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.98
|
| 57 | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.75
Deep-Palm: 0.97
|
|
| 120 | - | - | - |
Deep-Palm: 0.06
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.333
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
2
PC3
Specificity: 0.333
2/2 (100.0%)
2
cerebral cortex
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | C → Ffs*86 | 0.001969 | INS | Frame Shift Ins | HNSC |
| 20 | C → C | 0.001887 | SNP | Silent | UCEC |
| 42 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 189 | G → C | 0.002294 | SNP | Missense Mutation | OV |