Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PN25 | HSPA8 | Heat shock protein family A … | Homo sapiens (Human) | 132 aa |
Protein Details: E9PN25 (HSPA8)
Protein Information
| Accession | E9PN25 |
|---|---|
| Protein Names | Heat shock protein family A (Hsp70) member 8 |
| Gene Symbol | HSPA8 |
| Organism | Homo sapiens (Human) |
| Length | 132 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSKGPAVGID11LGTTYSCVGV21FQHGKVEIIA31NDQGNRTTPS41YVAFTDTERL
51-10051IGDAAKNQVA61MNPTNTVFDA71KRLIGRRFDD81AVVQSDMKHW91PFMVVNDAGR
101-132101PKVQVEYKGE111TKSFYPEEVS121SMVLTKMKEI131AE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 17 | SWISSPALM DBPTM CYSMODDB | ATPase, nucleotide binding domain Heat shock protein 70 family 70kDa heat shock protein signature Hsp70 protein |
HeLa
(29575903)
|
Unknown
(32651440)
cerebral cortex
(36430497)
|
Deep-Palm: 0.96
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.364
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
3
LNCaP
Specificity: 0.273
3/3 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 267 | C → W | 0.002020 | SNP | Missense Mutation | PRAD |
| 311 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 342 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 416 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 580 | W → C | 0.002033 | SNP | Missense Mutation | LUSC |