Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| E9PNG1 | TMEM63B | Transmembrane protein 63B | Homo sapiens (Human) | 226 aa |
Protein Details: E9PNG1 (TMEM63B)
Protein Information
| Accession | E9PNG1 |
|---|---|
| Protein Names | Transmembrane protein 63B |
| Gene Symbol | TMEM63B |
| Organism | Homo sapiens (Human) |
| Length | 226 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLPFLLATLG11TTALNNSNPK21DYCYSARIRS31TVLQGLPFGG41VPTVLALDFM
51-10051CFLALLFLFS61ILRKVAWDYG71RLALVTDADR81LRRQERDRVE91QEYVASAMHG
101-150101DSHDRYERLT111SVSSSVDFDQ121RDNGFCSWLT131AIFRIKDDEI141RDKCGGDAVH
151-200151YLSFQRHIIG161LLVVVGVLSV171GIVLPVNFSG181DLLENNAYSF191GRTTIANLKS
201-226201GNNLLWLHTS211FAFLYLLLTV221YSMRRH
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 23 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.86
|
|
| 51 | - | - | - |
Deep-Palm: 0.97
|
|
| 126 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.65
Deep-Palm: 0.69
|
| 144 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.68
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.300
3
LNCaP
Specificity: 0.300
3/3 (100.0%)
3
PC3
Specificity: 0.300
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.300
3/3 (100.0%)
1
DU145 cell
Specificity: 0.100
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 108 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 128 | W → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 231 | R → C | 0.007299 | SNP | Missense Mutation | READ |
| 303 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 394 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 431 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 433 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 542 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 580 | G → C | 0.002033 | SNP | Missense Mutation | THCA |
| 587 | R → C | 0.002747 | SNP | Missense Mutation | LIHC |
| 651 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 702 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 735 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |