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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
F5GWI0 DDB1 Damage specific DNA binding protein … Homo sapiens (Human) 370 aa

Protein Details: F5GWI0 (DDB1)

Protein Information
AccessionF5GWI0
Protein NamesDamage specific DNA binding protein 1
Gene SymbolDDB1
OrganismHomo sapiens (Human)
Length370 aa
IsoformsNo isoforms
Related PMIDs 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass)
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MYGKIAVMEL11FRPKGESKDL21LFILTAKYNA31CILEYKQSGE41SIDIITRAHG
51-10051NVQDRIGRPS61ETGIIGIIDP71ECRMIGLRLY81DGLFKVIPLD91RDNKELKAFN
101-150101IRLEELHVID111VKFLYGCQAP121TICFVYQDPQ131GRHVKTYEVS141LREKEFNKGP
151-200151WKQENVEAEA161SMVIAVPEPF171GGAIIIGQES181ITYHNGDKYL191AIAPPIIKQS
201-250201TIVCHNRVDP211NGSRYLLGDM221EGRLFMLLLE231KEEQMDGTVT241LKDLRVELLG
251-300251ETSIAECLTY261LDNGVVFVGS271RLGDSQLVKL281NVDSNEQGSY291VVAMETFTNL
301-350301GPIVDMCVVD311LERQGQGQLV321TCSGAFKEGS331LRIIRNGIGI341HEHASIDLPG
351-370351IKDHFSIGEV361GLSRTQSSGQ
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
31 WD40/YVTN repeat-like-containing domain superfamily - -
GPS-Palm: 0.91
Deep-Palm: 0.74
72 SWISSPALM DBPTM CYSMODDB RSE1/DDB1/CPSF1 first beta-propeller -
cerebral cortex (36430497)
Unknown (32651440)
Deep-Palm: 0.92
117 - - -
GPS-Palm: 0.81
Deep-Palm: 0.29
123 - - -
Deep-Palm: 0.22
204 - - -
Deep-Palm: 0.71
257 - - -
Deep-Palm: 0.98
307 - - -
Deep-Palm: 0.51
322 - -
cerebral cortex (36430497)
GPS-Palm: 0.77
Deep-Palm: 0.95
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
PC3
Specificity: 0.308
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
2
LNCaP
Specificity: 0.154
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.231
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). Blue bars: Literature data, Orange bars: Mass Spectrometry data. The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
147 R → C 0.001887 SNP Missense Mutation UCEC
158 R → C 0.002506 SNP Missense Mutation COAD
182 Y → C 0.002288 SNP Missense Mutation STAD
313 C → C 0.001887 SNP Silent UCEC
323 F → C 0.007299 SNP Missense Mutation READ
327 R → C 0.001969 SNP Missense Mutation HNSC
327 R → C 0.002141 SNP Missense Mutation SKCM
613 Y → C 0.002141 SNP Missense Mutation SKCM
642 R → C 0.002141 SNP Missense Mutation SKCM
655 R → C 0.001014 SNP Missense Mutation BRCA
713 R → C 0.004283 SNP Missense Mutation SKCM
713 R → C 0.001887 SNP Missense Mutation UCEC
819 C → C 0.002141 SNP Silent SKCM
928 R → C 0.002288 SNP Missense Mutation STAD
928 R → C 0.001887 SNP Missense Mutation UCEC
1047 W → Cfs*15 0.002976 INS Frame Shift Ins KIRC