Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5GXS2 | ACTN4; hCG_1996371 | Actinin alpha 4 (Actinin, alpha … | Homo sapiens (Human) | 911 aa |
Protein Details: F5GXS2 (ACTN4)
Protein Information
| Accession | F5GXS2 |
|---|---|
| Protein Names | Actinin alpha 4 (Actinin, alpha 4, isoform CRA_a) |
| Gene Symbol | ACTN4; hCG_1996371 |
| Organism | Homo sapiens (Human) |
| Length | 911 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 32944167 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.895
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
34
LNCaP cells
Specificity: 0.895
34/46 (73.9%)
4
PC3 cells
Specificity: 0.105
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MVDYHAANQS11YQYGPSSAGN21GAGGGGSMGD31YMAQEDDWDR41DLLLDPAWEK
51-10051QQRKTFTAWC61NSHLRKAGTQ71IENIDEDFRD81GLKLMLLLEV91ISGERLPKPE
101-150101RGKMRVHKIN111NVNKALDFIA121SKGVKLVSIG131AEEIVDGNAK141MTLGMIWTII
151-200151LRFAIQDISV161EETSAKEGLL171LWCQRKTAPY181KNVNVQNFHI191SWKDGLAFNA
201-250201LIHRHRPELI211EYDKLRKDDP221VTNLNNAFEV231AEKYLDIPKM241LDAEDIVGTL
251-300251RPDEKAIMTY261VSCFYHAFSG271AQKAETAANR281ICKVLAVNQE291NEHLMEDYEK
301-350301LASDLLEWIR311RTIPWLEDRV321PQKTIQEMQQ331KLEDFRDYRR341VHKPPKVQEK
351-400351CQLEINFNTL361QTKLRLSNRP371AFMPSEGKMV381SDINNGWQHL391EQAEKGYEEW
401-450401LLNEIRRLER411LDHLAEKFRQ421KASIHEAWTD431GKEAMLKHRD441YETATLSDIK
451-500451ALIRKHEAFE461SDLAAHQDRV471EQIAAIAQEL481NELDYYDSHN491VNTRCQKICD
501-550501QWDALGSLTH511SRREALEKTE521KQLEAIDQLH531LEYAKRAAPF541NNWMESAMED
551-600551LQDMFIVHTI561EEIEGLISAH571DQFKSTLPDA581DREREAILAI591HKEAQRIAES
601-650601NHIKLSGSNP611YTTVTPQIIN621SKWEKVQQLV631PKRDHALLEE641QSKQQSNEHL
651-700651RRQFASQANV661VGPWIQTKME671EIGRISIEMN681GTLEDQLSHL691KQYERSIVDY
701-750701KPNLDLLEQQ711HQLIQEALIF721DNKHTNYTME731HIRVGWEQLL741TTIARTINEV
751-800751ENQILTRDAK761GISQEQMQEF771RASFNHFDKD781HGGALGPEEF791KACLISLGYD
801-850801VENDRQGEAE811FNRIMSLVDP821NHSGLVTFQA831FIDFMSRETT841DTDTADQVIA
851-900851SFKVLAGDKN861FITAEELRRE871LPPDQAEYCI881ARMAPYQGPD891AVPGALDYKS
901-911901FSTALYGESD911L
Palmitoylation Sites Details
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 195 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 311 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 319 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 340 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 365 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 365 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 423 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 469 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 502 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 512 | R → C | 0.012195 | SNP | Missense Mutation | MESO |
| 536 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 584 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 651 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 695 | R → C | 0.002545 | SNP | Missense Mutation | GBM |
| 813 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 823 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 902 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |