Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5GXU9 | BCKDHA | 2-oxoisovalerate dehydrogenase subunit alpha (EC … | Homo sapiens (Human) | 328 aa |
Protein Details: F5GXU9 (BCKDHA)
Protein Information
| Accession | F5GXU9 |
|---|---|
| Protein Names | 2-oxoisovalerate dehydrogenase subunit alpha (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) |
| Gene Symbol | BCKDHA |
| Organism | Homo sapiens (Human) |
| Length | 328 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAVAIAAARV11WRLNRGLSQA21ALLLLRQPGA31RGLARSHPPR41QQQQFSSLDD
51-10051KPQFPGASAE61FIDKLEFIQP71NVISGIPIYR81VMDRQGQIIN91PSEDPHGRIS
101-150101FYMTNYGEEG111THVGSAAALD121NTDLVFGQYR131EAGVLMYRDY141PLELFMAQCY
151-200151GNISDLGKGR161QMPVHYGCKE171RHFVTISSPL181ATQIPQAVGA191AYAAKRANAN
201-250201RVVICYFGEG211AASEGDAHAG221FNFAATLECP231IIFFCRNNGY241AISTPTSEQY
251-300251RGDGIAARGP261GYGIMSIRVD271GNDVFAVYNA281TKEARRRAVA291ENQPFLIEAM
301-328301TYRIGHHSTS311DDSSAYRSVD321EVNYWDKQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 149 | - | - | - |
Deep-Palm: 0.75
|
|
| 168 | - | - | - |
GPS-Palm: 0.69
Deep-Palm: 0.78
|
|
| 205 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.94
|
|
| 229 | - | - | - |
Deep-Palm: 0.22
|
|
| 235 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.55
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
LNCaP
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 86 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 120 | Y → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 169 | Y → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 279 | Y → Cfs*34 | 0.002294 | INS | Frame Shift Ins | OV |
| 367 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |