Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5GXY2 | LDHA | L-lactate dehydrogenase A chain (LDH … | Homo sapiens (Human) | 156 aa |
Protein Details: F5GXY2 (LDHA)
Protein Information
| Accession | F5GXY2 |
|---|---|
| Protein Names | L-lactate dehydrogenase A chain (LDH muscle subunit) |
| Gene Symbol | LDHA |
| Organism | Homo sapiens (Human) |
| Length | 156 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MATLKDQLIY11NLLKEEQTPQ21NKITVVGVGA31VGMACAISIL41MKDLADELAL
51-10051VDVIEDKLKG61EMMDLQHGSL71FLRTPKIVSG81KDYNVTANSK91LVIITAGARQ
101-150101QEGESRLNLV111QRNVNIFKFI121IPNVVKYSPN131CKLLIVSNPV141DILTYVAWKI
151-156151SGFPKN
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 35 | L-lactate/malate dehydrogenase L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) NAD(P)-binding domain superfamily Lactate/malate dehydrogenase, N-terminal | - |
Unknown
(32651440)
|
GPS-Palm: 0.84
Deep-Palm: 0.96
|
|
| 131 | SWISSPALM DBPTM CYSMODDB | lactate/malate dehydrogenase NAD binding domain | - | - |
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
PC3
Specificity: 0.400
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 99 | R → C | 0.003460 | SNP | Missense Mutation | CESC |
| 106 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 157 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 171 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |