Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5GY55 | DDB1 | DNA damage-binding protein 1 | Homo sapiens (Human) | 1092 aa |
Protein Details: F5GY55 (DDB1)
Protein Information
| Accession | F5GY55 |
|---|---|
| Protein Names | DNA damage-binding protein 1 |
| Gene Symbol | DDB1 |
| Organism | Homo sapiens (Human) |
| Length | 1092 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 32944167 36430497 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.727
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
24
LNCaP cells
Specificity: 0.727
24/46 (52.2%)
4
PC3 cells
Specificity: 0.121
4/4 (100.0%)
4
Cerebral cortex
Specificity: 0.121
4/4 (100.0%)
1
U937 cells
Specificity: 0.030
1/1 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MSYNYVVTAQ11KPTAVNGCVT21GHFTSAEDLN31LLIAKNTRLE41IYVVTAEGLR
51-10051PVKEVGMYGK61IAVMELFRPK71GESKDLLFIL81TAKYNACILE91YKQSGESIDI
101-150101ITRAHGNVQD111RIGRPSETGI121IGIIDPECRM131IGLRLYDGLF141KVIPLDRDNK
151-200151ELKAFNIRLE161ELHVIDVKFL171YGCQAPTICF181VYQDPQGRHV191KTYEVSLREK
201-250201EFNKGPWKQE211NVEAEASMVI221AVPEPFGGAI231IIGQESITYH241NGDKYLAIAP
251-300251PIIKQSTIVC261HNRVDPNGSR271YLLGDMEGRL281FMLLLEKEEQ291MDGTVTLKDL
301-350301RVELLGETSI311AECLTYLDNG321VVFVGSRLGD331SQLVKLNVDS341NEQGSYVVAM
351-400351ETFTNLGPIV361DMCVVDLERQ371GQGQLVTCSG381AFKEGSLRII391RNGIGIHEHA
401-450401SIDLPGIKGL411WPLRSDPNRE421TDDTLVLSFV431GQTRVLMLNG441EEVEETELMG
451-500451FVDDQQTFFC461GNVAHQQLIQ471ITSASVRLVS481QEPKALVSEW491KEPQAKNISV
501-550501ASCNSSQVVV511AVGRALYYLQ521IHPQELRQIS531HTEMEHEVAC541LDITPLGDSN
551-600551GLSPLCAIGL561WTDISARILK571LPSFELLHKE581MLGGEIIPRS591ILMTTFESSH
601-650601YLLCALGDGA611LFYFGLNIET621GLLSDRKKVT631LGTQPTVLRT641FRSLSTTNVF
651-700651ACSDRPTVIY661SSNHKLVFSN671VNLKEVNYMC681PLNSDGYPDS691LALANNSTLT
701-750701IGTIDEIQKL711HIRTVPLYES721PRKICYQEVS731QCFGVLSSRI741EVQDTSGGTT
751-800751ALRPSASTQA761LSSSVSSSKL771FSSSTAPHET781SFGEEVEVHN791LLIIDQHTFE
801-850801VLHAHQFLQN811EYALSLVSCK821LGKDPNTYFI831VGTAMVYPEE841AEPKQGRIVV
851-900851FQYSDGKLQT861VAEKEVKGAV871YSMVEFNGKL881LASINSTVRL891YEWTTEKELR
901-950901TECNHYNNIM911ALYLKTKGDF921ILVGDLMRSV931LLLAYKPMEG941NFEEIARDFN
951-1000951PNWMSAVEIL961DDDNFLGAEN971AFNLFVCQKD981SAATTDEERQ991HLQEVGLFHL
1001-10501001GEFVNVFCHG1011SLVMQNLGET1021STPTQGSVLF1031GTVNGMIGLV1041TSLSESWYNL
1051-10921051LLDMQNRLNK1061VIKSVGKIEH1071SFHLEILSHR1081AEDRTSHRFH1091RR
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 87 | Prediction (High) | - | - |
| 128 | CYSMODDB SWISSPALM DBPTM | RSE1/DDB1/CPSF1 first beta-propeller | - |
| 173 | Prediction (Medium) | - | - |
| 378 | Prediction (Low) | - | - |
| 503 | Prediction (Medium) | - | - |
| 652 | Prediction (Medium) | - | - |
| 732 | Prediction (Low) | - | - |
| 819 | Prediction (Low) | - | - |
| 977 | Prediction (Low) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 147 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 158 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 182 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 313 | C → C | 0.001887 | SNP | Silent | UCEC |
| 323 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 327 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 327 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 613 | Y → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 642 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 655 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 713 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 713 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 819 | C → C | 0.002141 | SNP | Silent | SKCM |
| 928 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 928 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1047 | W → Cfs*15 | 0.002976 | INS | Frame Shift Ins | KIRC |