Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5GZS6 | SLC3A2 | Amino acid transporter heavy chain … | Homo sapiens (Human) | 599 aa |
Protein Details: F5GZS6 (SLC3A2)
Protein Information
| Accession | F5GZS6 |
|---|---|
| Protein Names | Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (Solute carrier family 3 member 2) |
| Gene Symbol | SLC3A2 |
| Organism | Homo sapiens (Human) |
| Length | 599 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MELQPPEASI11AVVSIPRQLP21GSHSEAGVQG31LSAGDDSETG41SDCVTQAGLQ
51-10051LLASSDPPAL61ASKNAEVTGT71MSQDTEVDMK81EVELNELEPE91KQPMNAASGA
101-150101AMSLAGAEKN111GLVKIKVAED121EAEAAAAAKF131TGLSKEELLK141VAGSPGWVRT
151-200151RWALLLLFWL161GWLGMLAGAV171VIIVRAPRCR181ELPAQKWWHT191GALYRIGDLQ
201-250201AFQGHGAGNL211AGLKGRLDYL221SSLKVKGLVL231GPIHKNQKDD241VAQTDLLQID
251-300251PNFGSKEDFD261SLLQSAKKKS271IRVILDLTPN281YRGENSWFST291QVDTVATKVK
301-350301DALEFWLQAG311VDGFQVRDIE321NLKDASSFLA331EWQNITKGFS341EDRLLIAGTN
351-400351SSDLQQILSL361LESNKDLLLT371SSYLSDSGST381GEHTKSLVTQ391YLNATGNRWC
401-450401SWSLSQARLL411TSFLPAQLLR421LYQLMLFTLP431GTPVFSYGDE441IGLDAAALPG
451-500451QPMEAPVMLW461DESSFPDIPG471AVSANMTVKG481QSEDPGSLLS491LFRRLSDQRS
501-550501KERSLLHGDF511HAFSAGPGLF521SYIRHWDQNE531RFLVVLNFGD541VGLSAGLQAS
551-599551DLPASASLPA561KADLLLSTQP571GREEGSPLEL581ERLKLEPHEG591LLLRFPYAA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 43 | FAM138 N-terminal domain signature | - | - |
Deep-Palm: 0.96
|
|
| 179 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.92
|
|
| 400 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.82
Deep-Palm: 0.90
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.400
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 430 | W → C | 0.002545 | SNP | Missense Mutation | GBM |
| 534 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 613 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |