Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5H245 | LDHC | L-lactate dehydrogenase (EC 1.1.1.27) | Homo sapiens (Human) | 318 aa |
Protein Details: F5H245 (LDHC)
Protein Information
| Accession | F5H245 |
|---|---|
| Protein Names | L-lactate dehydrogenase (EC 1.1.1.27) |
| Gene Symbol | LDHC |
| Organism | Homo sapiens (Human) |
| Length | 318 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MSTVKEQLIE11KLIEDDENSQ21CKITIVGTGA31VGMACAISIL41LKDLADELAL
51-10051VDVALDKLKG61EMMDLQHGSL71FFSTSKITSG81KAGARQQEGE91TRLALVQRNV
101-150101AIMKSIIPAI111VHYSPDCKIL121VVSNPVDILT131YIVWKISGLP141VTRVIGSGCN
151-200151LDSARFRYLI161GEKLGVHPTS171CHGWIIGEHG181DSSVPLWSGV191NVAGVALKTL
201-250201DPKLGTDSDK211EHWKNIHKQV221IQSAYEIIKL231KGYTSWAIGL241SVMDLVGSIL
251-300251KNLRRVHPVS261TMVKGLYGIK271EELFLSIPCV281LGRNGVSDVV291KINLNSEEEA
301-318301LFKKSAETLW311NIQKDLIF
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 21 | NAD(P)-binding domain superfamily Prokaryotic membrane lipoprotein lipid attachment site profile. L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) | - | - |
Deep-Palm: 0.70
|
|
| 35 | L-lactate/malate dehydrogenase L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) NAD(P)-binding domain superfamily Lactate/malate dehydrogenase, N-terminal | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.97
|
|
| 117 | - | - | - |
Deep-Palm: 0.85
|
|
| 149 | SWISSPALM DBPTM CYSMODDB | - | - |
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.97
|
| 171 | - | - | - |
Deep-Palm: 0.86
|
|
| 279 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
cerebral cortex
Specificity: 0.667
4/4 (100.0%)
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 106 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 112 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 112 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 157 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 157 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |