Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5H2L3 | DDB1 | Damage specific DNA binding protein … | Homo sapiens (Human) | 165 aa |
Protein Details: F5H2L3 (DDB1)
Protein Information
| Accession | F5H2L3 |
|---|---|
| Protein Names | Damage specific DNA binding protein 1 |
| Gene Symbol | DDB1 |
| Organism | Homo sapiens (Human) |
| Length | 165 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 36430497 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MYGKIAVMEL11FRPKGESKDL21LFILTAKYNA31CILEYKQSGE41SIDIITRAHG
51-10051NVQDRIGRPS61ETGIIGIIDP71ECRMIGLRLY81DGLFKVIPLD91RDNKELKAFN
101-150101IRLEELHVID111VKFLYGCQAP121TICFVYQDPQ131GRHVKTYEVS141LREKEFNKGP
151-165151WKQENVEAEA161SMVIA
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 31 | WD40/YVTN repeat-like-containing domain superfamily | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.74
|
|
| 72 | SWISSPALM DBPTM CYSMODDB | RSE1/DDB1/CPSF1 first beta-propeller | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
Deep-Palm: 0.92
|
| 117 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.29
|
|
| 123 | - | - | - |
Deep-Palm: 0.22
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
PC3
Specificity: 0.400
4/4 (100.0%)
4
cerebral cortex
Specificity: 0.400
4/4 (100.0%)
2
LNCaP
Specificity: 0.200
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 147 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 158 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 182 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 313 | C → C | 0.001887 | SNP | Silent | UCEC |
| 323 | F → C | 0.007299 | SNP | Missense Mutation | READ |
| 327 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 327 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 613 | Y → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 642 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 655 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 713 | R → C | 0.004283 | SNP | Missense Mutation | SKCM |
| 713 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 819 | C → C | 0.002141 | SNP | Silent | SKCM |
| 928 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 928 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 1047 | W → Cfs*15 | 0.002976 | INS | Frame Shift Ins | KIRC |