Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5H4D1 | ADCY7 | adenylate cyclase (EC 4.6.1.1) | Homo sapiens (Human) | 734 aa |
Protein Details: F5H4D1 (ADCY7)
Protein Information
| Accession | F5H4D1 |
|---|---|
| Protein Names | adenylate cyclase (EC 4.6.1.1) |
| Gene Symbol | ADCY7 |
| Organism | Homo sapiens (Human) |
| Length | 734 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31382980 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MPAKGRYFLN11EGEEGPDQDA21LYEKYQLTSQ31HGPLLLTLLL41VAATACVALI
51-10051IIAFSQGDPS61RHQAILGMAF71LVLAVFAALS81VLMYVECLLR91RWLRALALLT
101-150101WACLVALGYV111LVFDAWTKAA121CAWEQVPFFL131FIVFVVYTLL141PFSMRGAVAV
151-200151GAVSTASHLL161VLGSLMGGFT171TPSVRVGLQL181LANAVIFLCG191NLTGAFHKHQ
201-250201MQDASRDLFT211YTVKCIQIRR221KLRIEKRQQE231NLLLSVLPAH241ISMGMKLAII
251-300251ERLKEHGDRR261CMPDNNFHSL271YVKRHQNVSI281LYADIVGFTQ291LASDCSPKEL
301-350301VVVLNELFGK311FDQIAKANEC321MRIKILGDCY331YCVSGLPVSL341PTHARNCVKM
351-400351GLDMCQAIKQ361VREATGVDIN371MRVGIHSGNV381LCGVIGLRKW391QYDVWSHDVS
401-450401LANRMEAAGV411PGRVHITEAT421LKHLDKAYEV431EDGHGQQRDP441YLKEMNIRTY
451-500451LVIDPRSQQP461PPPSQHLPRP471KGDAALKMRA481SVRMTRYLES491WGAARPFAHL
501-550501NHRESVSSGE511THVPNGRRPK521SVPQRHRRTP531DRSMSPKGRS541EDDSYDDEML
551-600551SAIEGLSSTR561PCCSKSDDFY571TFGSIFLEKG581FEREYRLAPI591PRARHDFACA
601-650601SLIFVCILLV611HVLLMPRTAA621LGVSFGLVAC631VLGLVLGLCF641ATKFSRCCPA
651-700651RGTLCTISER661VETQPLLRLT671LAVLTIGSLL681TVAIINLPLM691PFQVPELPVG
701-734701NETGLLAASS711KTRALCEPLP721HLHTVFSRLN731ELTS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 46 | - | - | - |
Deep-Palm: 0.97
|
|
| 87 | - | - | - |
GPS-Palm: 0.94
Deep-Palm: 0.98
|
|
| 103 | - | - | - |
GPS-Palm: 0.81
Deep-Palm: 0.98
|
|
| 121 | - | - | - |
Deep-Palm: 0.55
|
|
| 189 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.75
|
|
| 215 | - | - | - |
GPS-Palm: 0.83
Deep-Palm: 0.82
|
|
| 261 | - | - | - |
Deep-Palm: 0.44
|
|
| 295 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.78
|
|
| 320 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.13
|
|
| 329 | - | - | - |
Deep-Palm: 0.31
|
|
| 332 | - | - | - |
Deep-Palm: 0.23
|
|
| 347 | - | - | - |
Deep-Palm: 0.63
|
|
| 355 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.38
|
|
| 382 | - | - | - |
GPS-Palm: 0.85
Deep-Palm: 0.37
|
|
| 562 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.66
|
|
| 563 | - | - | - |
Deep-Palm: 0.55
|
|
| 599 | - | - | - |
Deep-Palm: 0.67
|
|
| 606 | - | - | - |
Deep-Palm: 0.81
|
|
| 630 | - | - | - |
Deep-Palm: 0.98
|
|
| 639 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
|
| 647 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.98
|
|
| 648 | - | - | - |
GPS-Palm: 0.80
Deep-Palm: 0.98
|
|
| 655 | - | - | - |
GPS-Palm: 0.70
Deep-Palm: 0.93
|
|
| 716 | - | - | - |
GPS-Palm: 0.75
Deep-Palm: 0.98
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
U937 cell
Specificity: 1.000
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 67 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 80 | S → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 101 | W → C | 0.001014 | SNP | Missense Mutation | BRCA |
| 103 | C → F | 0.001764 | SNP | Missense Mutation | LUAD |
| 163 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 223 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 329 | C → C | 0.001887 | SNP | Silent | UCEC |
| 448 | R → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 630 | C → C | 0.001887 | SNP | Silent | UCEC |
| 648 | C → F | 0.001969 | SNP | Missense Mutation | HNSC |
| 715 | L → Cfs*23 | 0.001764 | DEL | Frame Shift Del | LUAD |
| 770 | C → C | 0.001887 | SNP | Silent | UCEC |
| 775 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 822 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 877 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 895 | C → C | 0.001887 | SNP | Silent | UCEC |
| 904 | C → R | 0.001969 | SNP | Missense Mutation | HNSC |
| 991 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 347* | C → ? | 0.001969 | SNP | Nonsense Mutation | HNSC |