Search Database

Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
F5H5A3 MAP4K3 Mitogen-activated protein kinase kinase kinase … Homo sapiens (Human) 810 aa

Protein Details: F5H5A3 (MAP4K3)

Protein Information
AccessionF5H5A3
Protein NamesMitogen-activated protein kinase kinase kinase kinase (EC 2.7.11.1)
Gene SymbolMAP4K3
OrganismHomo sapiens (Human)
Length810 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MMKDCKHPNI11VAYFGSYLRR21DKLWICMEFC31GGGSLQDIYH41VTGPLSELQI
51-10051AYVSRETLQG61LYYLHSKGKM71HRDIKGANIL81LTDNGHVKLA91DFGVSAQITA
101-150101TIAKRKSFIG111TPYWMAPEVA121AVERKGGYNQ131LCDLWAVGIT141AIELAELQPP
151-200151MFDLHPMRAL161FLMTKSNFQP171PKLKDKMKWS181NSFHHFVKMA191LTKNPKKRPT
201-250201AEKLLQHPFV211TQHLTRSLAI221ELLDKVNNPD231HSTYHDFDDD241DPEPLVAVPH
251-300251RIHSTSRNVR261EEKTRSEITF271GQVKFDPPLR281KETEPHHELD291LQLEYGQGHQ
301-350301GGYFLGANKS311LLKSVEEELH321QRGHVAHLED331DEGDDDESKH341STLKAKIPPP
351-400351LPPKPKSIFI361PQEMHSTEDE371NQGTIKRCPM381SGSPAKPSQV391PPRPPPPRLP
401-450401PHKPVALGNG411MSSFQLNGER421DGSLCQQQNE431HRGTNLSRKE441KKDVPKPISN
451-500451GLPPTPKVHM461GACFSKVFNG471CPLKIHCASS481WINPDTRDQY491LIFGAEEGIY
501-550501TLNLNELHET511SMEQLFPRRC521TWLYVMNNCL531LSISGKASQL541YSHNLPGLFD
551-600551YARQMQKLPV561AIPAHKLPDR571ILPRKFSVSA581KIPETKWCQK591CCVVRNPYTG
601-650601HKYLCGALQT611SIVLLEWVEP621MQKFMLIKHI631DFPIPCPLRM641FEMLVVPEQE
651-700651YPLVCVGVSR661GRDFNQVVRF671ETVNPNSTSS681WFTESDTPQT691NVTHVTQLER
701-750701DTILVCLDCC711IKIVNLQGRL721KSSRKLSSEL731TFDFQIESIV741CLQDSVLAFW
751-800751KHGMQGRSFR761SNEVTQEISD771STRIFRLLGS781DRVVVLESRP791TDNPTANSNL
801-810801YILAGHENSY
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
5 Protein kinase-like domain superfamily Phosphorylase Kinase STE20/SPS1-related Proline-Alanine-rich Kinase - -
GPS-Palm: 0.81
Deep-Palm: 0.02
26 Transferase(Phosphotransferase) domain 1 STE20/SPS1-related Proline-Alanine-rich Kinase Protein kinase domain Protein kinase-like domain superfamily - -
GPS-Palm: 0.72
Deep-Palm: 0.15
30 Transferase(Phosphotransferase) domain 1 STE20/SPS1-related Proline-Alanine-rich Kinase Protein kinase domain Protein kinase-like domain superfamily - -
GPS-Palm: 0.77
Deep-Palm: 0.30
132 - - -
Deep-Palm: 0.89
378 - - -
GPS-Palm: 0.67
Deep-Palm: 0.11
425 - - -
Deep-Palm: 0.53
463 - - -
Deep-Palm: 0.34
471 - - -
GPS-Palm: 0.76
Deep-Palm: 0.08
477 - - -
Deep-Palm: 0.12
520 SWISSPALM DBPTM CYSMODDB CNH domain - -
Deep-Palm: 0.26
529 SWISSPALM DBPTM CYSMODDB CNH domain - -
Deep-Palm: 0.63
588 - - -
GPS-Palm: 0.83
Deep-Palm: 0.12
591 - - -
GPS-Palm: 0.70
Deep-Palm: 0.10
592 - - -
GPS-Palm: 0.84
Deep-Palm: 0.14
605 - - -
GPS-Palm: 0.70
Deep-Palm: 0.51
636 - - -
GPS-Palm: 0.82
Deep-Palm: 0.28
655 - - -
Deep-Palm: 0.83
706 - - -
GPS-Palm: 0.88
Deep-Palm: 0.60
709 - - -
GPS-Palm: 0.90
Deep-Palm: 0.74
710 - - -
GPS-Palm: 0.88
Deep-Palm: 0.79
741 - - -
Deep-Palm: 0.16
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
27 Y → C 0.002506 SNP Missense Mutation COAD
76 Y → C 0.002506 SNP Missense Mutation COAD
125 Y → C 0.002294 SNP Missense Mutation OV
155 F → C 0.001887 SNP Missense Mutation UCEC
191 Y → C 0.005435 SNP Missense Mutation ESCA
228 K → Cfs*16 0.001887 INS Frame Shift Ins UCEC
328 R → C 0.001887 SNP Missense Mutation UCEC
577 F → C 0.001887 SNP Missense Mutation UCEC
793 C → C 0.002294 SNP Splice Region OV