Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F5H8F7 | ASH2L | ASH2 like, histone lysine methyltransferase … | Homo sapiens (Human) | 489 aa |
Protein Details: F5H8F7 (ASH2L)
Protein Information
| Accession | F5H8F7 |
|---|---|
| Protein Names | ASH2 like, histone lysine methyltransferase complex subunit |
| Gene Symbol | ASH2L |
| Organism | Homo sapiens (Human) |
| Length | 489 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MTNYSFHCNV11CHHSGNTYFL21RKQANLKEMC31LSALANLTWQ41SRTQDEHPKT
51-10051MFSKDKDIIP61FIDKYWECMT71TRQRPGKMTW81PNNIVKTMSK91ERDVFLVKEH
101-150101PDPGSKDPEE111DYPKFGLLDQ121DLSNIGPAYD131NQKQSSAVST141SGNLNGGIAA
151-200151GSSGKGRGAK161RKQQDGGTTG171TTKKARSDPL181FSAQRLPPHG191YPLEHPFNKD
201-250201GYRYILAEPD211PHAPDPEKLE221LDCWAGKPIP231GDLYRACLYE241RVLLALHDRA
251-300251PQLKISDDRL261TVVGEKGYSM271VRASHGVRKG281AWYFEITVDE291MPPDTAARLG
301-350301WSQPLGNLQA311PLGYDKFSYS321WRSKKGTKFH331QSIGKHYSSG341YGQGDVLGFY
351-400351INLPEDTETA361KSLPDTYKDK371ALIKFKSYLY381FEEKDFVDKA391EKSLKQTPHS
401-450401EIIFYKNGVN411QGVAYKDIFE421GVYFPAISLY431KSCTVSINFG441PCFKYPPKDL
451-489451TYRPMSDMGW461GAVVEHTLAD471VLYHVETEVD481GRRSPPWEP
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 8 | Set1/Ash2 histone methyltransferase complex subunit ASH2-like, PHD zinc finger | - | - |
Deep-Palm: 0.01
|
|
| 11 | Set1/Ash2 histone methyltransferase complex subunit ASH2-like, PHD zinc finger | - | - |
Deep-Palm: 0.02
|
|
| 30 | Set1/Ash2 histone methyltransferase complex subunit ASH2-like, winged-helix | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.92
|
|
| 68 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.15
|
|
| 223 | - | - | - |
Deep-Palm: 0.85
|
|
| 237 | - | - | - |
GPS-Palm: 0.76
Deep-Palm: 0.96
|
|
| 433 | - | - | - |
Deep-Palm: 0.17
|
|
| 442 | - | - | - |
Deep-Palm: 0.37
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
1
LNCaP
Specificity: 0.500
1/1 (100.0%)
1
U937 cell
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 130 | G → C | 0.002506 | SNP | Missense Mutation | COAD |
| 207 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 422 | Y → C | 0.005435 | SNP | Missense Mutation | ESCA |
| 525 | F → Cfs*3 | 0.002288 | DEL | Frame Shift Del | STAD |
| 558 | F → C | 0.001887 | SNP | Missense Mutation | UCEC |