Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F6U236 | PACSIN1 | Protein kinase C and casein … | Homo sapiens (Human) | 402 aa |
Protein Details: F6U236 (PACSIN1)
Protein Information
| Accession | F6U236 |
|---|---|
| Protein Names | Protein kinase C and casein kinase substrate in neurons 1 |
| Gene Symbol | PACSIN1 |
| Organism | Homo sapiens (Human) |
| Length | 402 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MNCVQERAKI11EKAYGQQLTD21WAKRWRQLIE31KGPQYGSLER41AWGAIMTEAD
51-10051KVSELHQEVK61NNLLNEDLEK71VKNWQKDAYH81KQIMGGFKET91KEAEDGFRKA
101-150101QKPWAKKMKE111LEAAKKAYHL121ACKEEKLAMT131REMNSKTEQS141VTPEQQKKLQ
151-200151DKVDKCKQDV161QKTQEKYEKV171LEDVGKTTPQ181YMENMEQVFE191QCQQFEEKRL
201-250201VFLKEVLLDI211KRHLNLAENS221SYIHVYRELE231QAIRGADAQE241DLRWFRSTSG
251-300251PGMPMNWPQF261EEWNPDLPHT271TTKKEKQPKK281AEGVALTNAT291GAVESTSQAG
301-350301DRGSVSSYDR311GQPYATEWSD321DESGNPFGGS331ETNGGANPFE341DDSKGVRVRA
351-400351LYDYDGQEQD361ELSFKAGDEL371TKLGEEDEQG381WCRGRLDSGQ391LGLYPANYVE
401-402401AI
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 3 | SWISSPALM DBPTM CYSMODDB | FCH domain Fes/CIP4 and EFC/F-BAR homology domain AH/BAR domain superfamily | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.04
|
| 122 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.96
|
|
| 156 | - | - | - |
Deep-Palm: 0.87
|
|
| 192 | - | - | - |
Deep-Palm: 0.66
|
|
| 382 | - | - |
cerebral cortex
(36430497)
|
Deep-Palm: 0.80
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
cerebral cortex
Specificity: 0.571
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
3
Cerebral Cortex (Mass)
Specificity: 0.429
3/4 (75.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 20 | W → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 177 | S → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 288 | R → C | 0.005013 | SNP | Missense Mutation | COAD |
| 294 | G → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 344 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 389 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 390 | V → Cfs*97 | 0.002506 | DEL | Frame Shift Del | COAD |
| 425 | R → C | 0.001014 | SNP | Missense Mutation | BRCA |