Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F8VQ14 | CCT2 | T-complex protein 1 subunit beta … | Homo sapiens (Human) | 416 aa |
Protein Details: F8VQ14 (CCT2)
Protein Information
| Accession | F8VQ14 |
|---|---|
| Protein Names | T-complex protein 1 subunit beta (CCT-beta) |
| Gene Symbol | CCT2 |
| Organism | Homo sapiens (Human) |
| Length | 416 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 31251020 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MASLSLAPVN11IFKAGADEER21AETARLTSFI31GAIAIGDLVK41STLGPKGMDK
51-10051ILLSSGRDAS61LMVTNDGATI71LKNIGVDNPA81AKVLVDMSRV91QDDEVGDGTT
101-150101SVTVLAAELL111REAESLIAKK121IHPQTIIAGW131REATKAAREA141LLSSAVDHGS
151-200151DEVKFRQDLM161NIAGTTLSSK171LLTHHKDHFT181KLAVEAVLRL191KGSGNLEAIH
201-250201IIKKLGGSLA211DSYLDEGFLL221DKKIGVNQPK231RIENAKILIA241NTGMDTDKIK
251-300251IFGSRVRVDS261TAKVAEIEHA271EKEKMKEKVE281RILKHGINCF291INRQLIYNYP
301-350301EQLFGAAGVM311AIEHADFAGV321ERLALVTGGE331IASTFDHPEL341VKLGSCKLIE
351-400351EVMIGEDKLI361HFSGVALGEA371CTIVLRGATQ381QILDEAERSL391HDALCVLAQT
401-416401VKDSRTVYGG411VANHHS
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 289 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.91
|
|
| 346 | - | - | - |
Deep-Palm: 0.96
|
|
| 371 | - | - |
Unknown
(32651440)
|
GPS-Palm: 0.84
Deep-Palm: 0.97
|
|
| 395 | SWISSPALM DBPTM CYSMODDB | TCP-1/cpn60 chaperonin family | - |
cerebral cortex
(36430497)
Unknown
(32651440)
|
GPS-Palm: 0.78
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
PC3
Specificity: 0.267
4/4 (100.0%)
3
LNCaP
Specificity: 0.200
3/3 (100.0%)
3
cerebral cortex
Specificity: 0.200
3/3 (100.0%)
1
Jurkat T cell
Specificity: 0.067
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.267
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 371 | C → C | 0.001887 | SNP | Silent | UCEC |
| 438 | S → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 456 | Y → C | 0.002747 | SNP | Missense Mutation | LIHC |