Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F8VVM2 | SLC25A3 | Solute carrier family 25 member … | Homo sapiens (Human) | 324 aa |
Protein Details: F8VVM2 (SLC25A3)
Protein Information
| Accession | F8VVM2 |
|---|---|
| Protein Names | Solute carrier family 25 member 3 (Phosphate carrier protein, mitochondrial) (Phosphate transport protein) |
| Gene Symbol | SLC25A3 |
| Organism | Homo sapiens (Human) |
| Length | 324 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19137006 31251020 31382980 32944167 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MFSSVAHLAR11ANPFNTPHLQ21LVHDGLGDLR31SSSPGPTGQP41RRPRNLAAAA
51-10051VEEYSCEFGS61AKYYALCGFG71GVLSCGLTHT81AVVPLDLVKC91RMQVDPQKYK
101-150101GIFNGFSVTL111KEDGVRGLAK121GWAPTFLGYS131MQGLCKFGFY141EVFKVLYSNM
151-200151LGEENTYLWR161TSLYLAASAS171AEFFADIALA181PMEAAKVRIQ191TQPGYANTLR
201-250201DAAPKMYKEE211GLKAFYKGVA221PLWMRQIPYT231MMKFACFERT241VEALYKFVVP
251-300251KPRSECSKPE261QLVVTFVAGY271IGVWKGLFAR281IIMIGTLTAL291QWFIYDSVKV
301-324301YFRLPRPPPP311EMPESLKKKL321GLTQ
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 56 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.91
|
|
| 67 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.82
|
|
| 75 | - | - |
Unknown
(32651440)
|
Deep-Palm: 0.82
|
|
| 90 | - | - | - |
GPS-Palm: 0.68
Deep-Palm: 0.93
|
|
| 135 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.65
Deep-Palm: 0.46
|
|
| 236 | SWISSPALM DBPTM CYSMODDB | Mitochondrial carrier protein |
HeLa
(29575903)
| - |
GPS-Palm: 0.85
Deep-Palm: 0.49
|
| 256 | - | - | - |
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.308
4
cerebral cortex
Specificity: 0.222
4/4 (100.0%)
3
LNCaP
Specificity: 0.167
3/3 (100.0%)
3
PC3
Specificity: 0.167
3/3 (100.0%)
2
Jurkat T cell
Specificity: 0.111
2/2 (100.0%)
1
U937 cell
Specificity: 0.056
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.222
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.056
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 117 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 353 | S → C | 0.003460 | SNP | Missense Mutation | CESC |