Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F8W1A4 | AK2 | Adenylate kinase 2, mitochondrial (AK … | Homo sapiens (Human) | 232 aa |
Protein Details: F8W1A4 (AK2)
Protein Information
| Accession | F8W1A4 |
|---|---|
| Protein Names | Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) |
| Gene Symbol | AK2 |
| Organism | Homo sapiens (Human) |
| Length | 232 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 31382980 |
| Database Sources | No database sources |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MAPSVPAAEP11EYPKGIRAVL21LGPPGAGKGT31QAPRLAENFC41VCHLATGDML
51-10051RAMVASGSEL61GKKLKATMDA71GKLVSDEMVV81ELIEKNLETP91LCKNGFLLDG
101-150101FPRTVRQAEM111LDDLMEKRKE121KLDSVIEFSI131PDSLLIRRIT141GRLIHPKSGR
151-200151SYHEEFNPPK161EPMKDDITGE171PLIRRSDDNE181KALKIRLQAY191HTQTTPLIEY
201-232201YRKRGIHSAI211DASQTPDVVF221ASILAAFSKA231TC
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 40 | P-loop containing nucleoside triphosphate hydrolase Adenylate kinase Adenylate kinase/UMP-CMP kinase | - | - |
Deep-Palm: 0.98
|
|
| 42 | Adenylate kinase/UMP-CMP kinase Adenylate kinase P-loop containing nucleoside triphosphate hydrolase | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.98
|
|
| 92 | - | - | - |
Deep-Palm: 0.97
|
|
| 232 | - | - | - |
GPS-Palm: 0.97
Deep-Palm: 0.03
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.750
3
LNCaP
Specificity: 0.750
3/3 (100.0%)
1
U937 cell
Specificity: 0.250
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 174 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |