Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| F8WBG6 | TM4SF1 | Transmembrane 4 L six family … | Homo sapiens (Human) | 103 aa |
Protein Details: F8WBG6 (TM4SF1)
Protein Information
| Accession | F8WBG6 |
|---|---|
| Protein Names | Transmembrane 4 L six family member 1 |
| Gene Symbol | TM4SF1 |
| Organism | Homo sapiens (Human) |
| Length | 103 aa |
| Isoforms | No isoforms |
| Related PMIDs | 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MCYGKCARCI11GHSLVGLALL21CIAANILLYF31PNGETKYASE41NHLSRFVWFF
51-10051SGIVGGGLLM61LLPAFVFIGL71EQDDCCGCCG81HENCGKRCAV91GPPALVVKMT
101-103101PKM
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 2 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.01
|
|
| 6 | SWISSPALM DBPTM CYSMODDB | L6 membrane L6 membrane protein |
HeLa
(29575903)
| - |
GPS-Palm: 0.87
Deep-Palm: 0.02
|
| 9 | SWISSPALM DBPTM CYSMODDB | L6 membrane L6 membrane protein |
HeLa
(29575903)
| - |
Deep-Palm: 0.04
|
| 21 | L6 membrane | - | - |
Deep-Palm: 0.94
|
|
| 75 | - | - | - |
Deep-Palm: 0.15
|
|
| 76 | - | - | - |
Deep-Palm: 0.28
|
|
| 78 | - | - | - |
GPS-Palm: 0.66
Deep-Palm: 0.10
|
|
| 79 | - | - | - |
Deep-Palm: 0.09
|
|
| 84 | - | - | - |
Deep-Palm: 0.17
|
|
| 88 | - | - | - |
Deep-Palm: 0.14
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
2
PC3
Specificity: 1.000
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 21 | C → F | 0.002506 | SNP | Missense Mutation | COAD |
| 21 | C → S | 0.002294 | SNP | Missense Mutation | OV |
| 29 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 77 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 84 | C → G | 0.001764 | SNP | Missense Mutation | LUAD |
| 84 | C → Wfs*39 | 0.004219 | DEL | Frame Shift Del | SARC |
| 107 | C → S | 0.001764 | SNP | Missense Mutation | LUAD |
| ? | ? → ? | 0.001887 | SNP | Missense Mutation | UCEC |