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Select Protein (1 found)

UniProt ID Gene Symbol Protein Name Organism Length Action
F8WCH9 HACL1 2-hydroxyacyl-CoA lyase 1 Homo sapiens (Human) 137 aa

Protein Details: F8WCH9 (HACL1)

Protein Information
Accession F8WCH9
Protein Names 2-hydroxyacyl-CoA lyase 1
Gene Symbol HACL1
Organism Homo sapiens (Human)
Length 137 aa
Isoforms No isoforms
Related PMIDs 31251020 32944167
Database Sources No database sources
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.973
Bubble Size: Positive Samples Count Color Intensity: Positive Ratio
36
LNCaP cells
Specificity: 0.973
36/46 (78.3%)
1
PC3 cells
Specificity: 0.027
1/4 (25.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID). The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples. Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MPDSNFAERS11EEQVSGAKVI21AQALKTQDVE31YIFGIVGIPV41TEIAIAAQQL
51-10051GIKYIGMRNE61QAACYAASAI71GYLTSRPGVC81LVVSGPGLIH91ALGGMANANM
101-137101NCWPLLVIGG111SSERNQETMG121AFQEFPQVHG131TLHVTSY
Palmitoylation Sites Details
Position Sources Domains Experimental PMIDs
64 Prediction (Low) - -
102 Prediction (Low) - -
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
140 R → C 0.002506 SNP Missense Mutation COAD
166 C → C 0.001887 SNP Silent UCEC
183 S → C 0.002427 SNP Missense Mutation BLCA
223 G → C 0.001887 SNP Missense Mutation UCEC
289 F → C 0.002506 SNP Missense Mutation COAD
301 F → C 0.002545 SNP Missense Mutation GBM
392 C → C 0.001887 SNP Silent UCEC
432 F → C 0.005435 SNP Missense Mutation ESCA