Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| G3V2N5 | ACTN1 | Actinin alpha 1 | Homo sapiens (Human) | 260 aa |
Protein Details: G3V2N5 (ACTN1)
Protein Information
| Accession | G3V2N5 |
|---|---|
| Protein Names | Actinin alpha 1 |
| Gene Symbol | ACTN1 |
| Organism | Homo sapiens (Human) |
| Length | 260 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDB dbPTM SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.852
Bubble Size: Positive Samples Count
Color Intensity: Positive Ratio
23
LNCaP cells
Specificity: 0.852
23/46 (50.0%)
4
PC3 cells
Specificity: 0.148
4/4 (100.0%)
0
Jurkat T cells
Specificity: 0.000
0/25 (0.0%)
0
U937 cells
Specificity: 0.000
0/1 (0.0%)
0
DU145 cells
Specificity: 0.000
0/2 (0.0%)
0
HeLa cells
Specificity: 0.000
0/1 (0.0%)
0
T cells
Specificity: 0.000
0/4 (0.0%)
0
HAP1 cells
Specificity: 0.000
0/10 (0.0%)
0
293T cells
Specificity: 0.000
0/10 (0.0%)
0
CEMx174 cells
Specificity: 0.000
0/3 (0.0%)
0
Endothelial cells
Specificity: 0.000
0/2 (0.0%)
0
Prefrontal cortex
Specificity: 0.000
0/1 (0.0%)
0
Cerebral cortex
Specificity: 0.000
0/4 (0.0%)
0
Liver membrane
Specificity: 0.000
0/1 (0.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Bars are grouped by tissue/cell line for easy comparison.
Protein Sequence
Single Types:
Experimental Database High Prediction Medium Prediction Low Prediction
Experimental Database High Prediction Medium Prediction Low Prediction
Combined Types:
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
All Three Exp + DB Exp + High Pred Exp + Med Pred Exp + Low Pred DB + High Pred DB + Med Pred DB + Low Pred Cysteine
1-501MGLRYVLPLR11PPGKTFTAWC21NSHLRKAGTQ31IENIEEDFRD41GLKLMLLLEV
51-10051ISGERLAKPE61RGKMRVHKIS71NVNKALDFIA81SKGVKLVSIG91AEEIVDGNVK
101-150101MTLGMIWTII111LRFAIQDISV121EETSAKEGLL131LWCQRKTAPY141KNVNIQNFHI
151-200151SWKDGLGFCA161LIHRHRPELI171DYGKLRKDDP181LTNLNTAFDV191AEKYLDIPKM
201-250201LDAEDIVGTA211RPDEKAIMTY221VSSFYHAFSG231AQKAETAANR241ICKVLAVNQE
251-260251NEQLMEDYEK
Palmitoylation Sites Details
| Position | Sources | Domains | Experimental PMIDs |
|---|---|---|---|
| 20 | Prediction (High) | - | - |
| 133 | CYSMODDB SWISSPALM DBPTM Prediction (High) | Calponin homology (CH) domain | - |
| 159 | Prediction (High) | - | - |
| 242 | Prediction (Medium) | - | - |
Conservation Scores
PhyloP
PhastCons
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 41 | C → C | 0.001887 | SNP | Silent | UCEC |
| 250 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 321 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 377 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 480 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 632 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 714 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 717 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 803 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 849 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 850 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 850 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |