Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| G3V2W4 | ACTN1 | Actinin alpha 1 | Homo sapiens (Human) | 238 aa |
Protein Details: G3V2W4 (ACTN1)
Protein Information
| Accession | G3V2W4 |
|---|---|
| Protein Names | Actinin alpha 1 |
| Gene Symbol | ACTN1 |
| Organism | Homo sapiens (Human) |
| Length | 238 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 32944167 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MLLLEVISGE11RLAKPERGKM21RVHKISNVNK31ALDFIASKGV41KLVSIGAEEI
51-10051VDGNVKMTLG61MIWTIILRFA71IQDISVEETS81AKEGLLLWCQ91RKTAPYKNVN
101-150101IQNFHISWKD111GLGFCALIHR121HRPELIDYGK131LRKDDPLTNL141NTAFDVAEKY
151-200151LDIPKMLDAE161DIVGTARPDE171KAIMTYVSSF181YHAFSGAQKA191ETAANRICKV
201-238201LAVNQENEQL211MEDYEKLASD221LLEWIRRTIP231WLENRVPE
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 89 | SWISSPALM DBPTM CYSMODDB | Calponin homology (CH) domain |
HeLa
(29575903)
| - |
GPS-Palm: 0.96
Deep-Palm: 0.96
|
| 115 | - | - | - |
GPS-Palm: 0.91
Deep-Palm: 0.70
|
|
| 198 | - | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.84
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.667
4
PC3
Specificity: 0.667
4/4 (100.0%)
2
LNCaP
Specificity: 0.333
2/2 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 41 | C → C | 0.001887 | SNP | Silent | UCEC |
| 250 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 321 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 377 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 480 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |
| 632 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 714 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 717 | W → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 803 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 849 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 850 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 850 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |