Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| G3XAC1 | SLC26A6 | Solute carrier family 26 member … | Homo sapiens (Human) | 651 aa |
Protein Details: G3XAC1 (SLC26A6)
Protein Information
| Accession | G3XAC1 |
|---|---|
| Protein Names | Solute carrier family 26 member 6 (Solute carrier family 26, member 6, isoform CRA_i) |
| Gene Symbol | SLC26A6 |
| Organism | Homo sapiens (Human) |
| Length | 651 aa |
| Isoforms | No isoforms |
| Related PMIDs | 31251020 |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MGLADASGPR11DTQALLSATQ21AMDLRRRDYH31MERPLLNQEH41LEELGRWGSA
51-10051PRTHQWRTWL61QCSRARAYAL71LLQHLPVLVW81LPRYPVRDWL91LGDLLSGLSV
101-150101AIMQLPQGLA111YALLAGLPPV121FGLYSSFYPV131FIYFLFGTSR141HISVVLEVCW
151-200151KLPQSKVGTV161VTAAVAGVVL171VVVKLLNDKL181QQQLPMPIPG191ELLTLIGATG
201-250201ISYGMGLKHR211FEVDVVGNIP221AGLVPPVAPN231TQLFSKLVGS241AFTIAVVGFA
251-300251IAISLGKIFA261LRHGYRVDSN271QELVALGLSN281LIGGIFQCFP291VSCSMSRSLV
301-350301QESTGGNSQV311AGAISSLFIL321LIIVKLGELF331HDLPKAVLAA341IIIVNLKGML
351-400351RQLSDMRSLW361KANRADLLIW371LVTFTATILL381NLDLGLVVAV391IFSLLLVVVR
401-450401TQMPHYSVLG411QVPDTDIYRD421VAEYSEAKEV431RGVKVFRSSA441TVYFANAEFY
451-500451SDALKQRCGV461DVDFLISQKK471KLLKKQEQLK481LKQLQKEEKL491RKQAASPKGA
501-550501SVSINVNTSL511EDMRSNNVED521CKMMVSSGDK531MEDATANGQE541DSKAPDGSTL
551-600551KALGLPQPDF561HSLILDLGAL571SFVDTVCLKS581LKNIFHDFRE591IEVEVYMAAC
601-650601HSPVVSQLEA611GHFFDASITK621KHLFASVHDA631VTFALQHPRP641VPDSPVSVTR
651-651651L
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 62 | SWISSPALM DBPTM CYSMODDB | - |
HeLa
(29575903)
| - |
GPS-Palm: 0.76
Deep-Palm: 0.93
|
| 149 | - | - | - |
GPS-Palm: 0.77
Deep-Palm: 0.91
|
|
| 288 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.86
|
|
| 293 | - | - | - |
GPS-Palm: 0.74
Deep-Palm: 0.59
|
|
| 458 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.65
Deep-Palm: 0.83
|
|
| 521 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.11
|
|
| 577 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.93
|
|
| 600 | - | - | - |
Deep-Palm: 0.29
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
LNCaP
Specificity: 1.000
4/4 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.000Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 87 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 97 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 531 | Y → C | 0.002506 | SNP | Missense Mutation | COAD |
| 544 | R → C | 0.002033 | SNP | Missense Mutation | LUSC |
| 544 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 683 | T → _V684insHYSECACEGGF | 0.005435 | INS | In Frame Ins | ESCA |
| 400* | C → ? | 0.002288 | SNP | Nonsense Mutation | STAD |