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UniProt ID Gene Symbol Protein Name Organism Length Action
G3XAL1 NOD1 Caspase recruitment domain family, member … Homo sapiens (Human) 779 aa

Protein Details: G3XAL1 (NOD1)

Protein Information
AccessionG3XAL1
Protein NamesCaspase recruitment domain family, member 4, isoform CRA_c (Nucleotide binding oligomerization domain containing 1)
Gene SymbolNOD1
OrganismHomo sapiens (Human)
Length779 aa
IsoformsNo isoforms
Related PMIDs No related PMIDs
Database SourcesCysModDBdbPTMSwissPalm
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
1-501MEEQGHSEME11IIPSESHPHI21QLLKSNRELL31VTHIRNTQCL41VDNLLKNDYF
51-10051SAEDAEIVCA61CPTQPDKVRK71ILDLVQSKGE81EVSEFFLYLL91QQLADAYVDL
101-150101RPWLLEIGFS111PSLLTQSKVV121VNTDPVSRYT131QQLRHHLGRD141SKFVLCYAQK
151-200151EELLLEEIYM161DTIMELVGFS171NESLGSLNSL181ACLLDHTTGI191LNEQGETIFI
201-250201LGDAGVGKSM211LLQRLQSLWA221TGRLDAGVKF231FFHFRCRMFS241CFKESDRLCL
251-300251QDLLFKHYCY261PERDPEEVFA271FLLRFPHVAL281FTFDGLDELH291SDLDLSRVPD
301-350301SSCPWEPAHP311LVLLANLLSG321KLLKGASKLL331TARTGIEVPR341QFLRKKVLLR
351-400351GFSPSHLRAY361ARRMFPERAL371QDRLLSQLEA381NPNLCSLCSV391PLFCWIIFRC
401-450401FQHFRAAFEG411SPQLPDCTMT421LTDVFLLVTE431VHLNRMQPSS441LVQRNTRSPV
451-500451ETLHAGRDTL461CSLGQVAHRG471MEKSLFVFTQ481EEVQASGLQE491RDMQLGFLRA
501-550501LPELGPGGDQ511QSYEFFHLTL521QAFFTAFFLV531LDDRVGTQEL541LRFFQEWMPP
551-600551AGAATTSCYP561PFLPFQCLQG571SGPAREDLFK581NKDHFQFTNL591FLCGLLSKAK
601-650601QKLLRHLVPA611AALRRKRKAL621WAHLFSSLRG631YLKSLPRVQV641ESFNQVQAMP
651-700651TFIWMLRCIY661ETQSQKVGQL671AARGICANYL681KLTYCNACSA691DCSALSFVLH
701-750701HFPKRLALDL711DNNNLNDYGV721RELQPCFSRL731TVLRLSVNQI741TDGGVKVLSE
751-779751ELTKYKIVTY761LGLWKSVDTI771CFKKQGLLK
Palmitoylation Sites Details
Position Database Domains Literature (PMID/Cell-Tissue) Mass(PMID/Cell-Tissue) Prediction Scores
39 CARD domain Death-like domain superfamily - -
GPS-Palm: 0.90
Deep-Palm: 0.93
59 - - -
Deep-Palm: 0.90
61 - - -
GPS-Palm: 0.91
Deep-Palm: 0.85
146 - - -
GPS-Palm: 0.82
Deep-Palm: 0.86
182 - - -
GPS-Palm: 0.70
Deep-Palm: 0.93
236 - - -
GPS-Palm: 0.69
Deep-Palm: 0.72
241 - - -
GPS-Palm: 0.80
Deep-Palm: 0.60
249 SWISSPALM DBPTM CYSMODDB NACHT domain - -
GPS-Palm: 0.82
Deep-Palm: 0.31
259 - - -
Deep-Palm: 0.91
303 - - -
Deep-Palm: 0.97
385 - - -
Deep-Palm: 0.92
388 - - -
Deep-Palm: 0.66
394 - - -
GPS-Palm: 0.68
Deep-Palm: 0.15
400 - - -
Deep-Palm: 0.22
417 - - -
Deep-Palm: 0.71
461 - - -
GPS-Palm: 0.77
Deep-Palm: 0.84
558 - - -
Deep-Palm: 0.43
567 - - -
Deep-Palm: 0.91
593 - - -
GPS-Palm: 0.92
Deep-Palm: 0.70
658 - - -
GPS-Palm: 0.68
Deep-Palm: 0.42
676 - - -
GPS-Palm: 0.83
Deep-Palm: 0.79
685 - - -
Deep-Palm: 0.72
688 - - -
Deep-Palm: 0.30
692 - - -
Deep-Palm: 0.68
726 - - -
GPS-Palm: 0.84
Deep-Palm: 0.90
771 - - -
GPS-Palm: 0.94
Deep-Palm: 0.15
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information

Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.

Position Amino Acid Change Frequency Type Function Cancer Type
144 V → Cfs*33 0.002288 DEL Frame Shift Del STAD
173 S → C 0.002545 SNP Missense Mutation GBM
235 R → C 0.007299 SNP Missense Mutation READ
297 R → C 0.002288 SNP Missense Mutation STAD
297 R → C 0.003460 SNP Missense Mutation CESC
425 F → C 0.005435 SNP Missense Mutation ESCA
572 G → C 0.001764 SNP Missense Mutation LUAD
591 F → C 0.002294 SNP Missense Mutation OV
617 R → C 0.002288 SNP Missense Mutation STAD
676 C → C 0.002545 SNP Silent GBM
783 C → Y 0.002506 SNP Missense Mutation COAD
59* C → ? 0.002294 SNP Nonsense Mutation OV