Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| G5E9R0 | ACTB | Actin beta (HCG15971, isoform CRA_b) | Homo sapiens (Human) | 125 aa |
Protein Details: G5E9R0 (ACTB)
Protein Information
| Accession | G5E9R0 |
|---|---|
| Protein Names | Actin beta (HCG15971, isoform CRA_b) |
| Gene Symbol | ACTB |
| Organism | Homo sapiens (Human) |
| Length | 125 aa |
| Isoforms | No isoforms |
| Related PMIDs | 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501MDDDIAALVV11DNGSGMCKAG21FAGDDAPRAV31FPSIVGRPRH41QGVMVGMGQK
51-10051DSYVGDEAQS61KRGILTLKYP71IEHGIVTNWD81DMEKIWHHTF91YNELRVAPEE
101-125101HPVLLTEAPL111NPKANREKMT121QDSLL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 17 | SWISSPALM DBPTM CYSMODDB | Actin ATPase, nucleotide binding domain Actin family |
HeLa
(29575903)
|
cerebral cortex
(36430497)
LNCaP
(31251020)
Unknown
(32651440)
|
Deep-Palm: 0.93
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
cerebral cortex
Specificity: 0.500
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.500
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 69 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 86 | W → C | 0.027027 | SNP | Missense Mutation | DLBC |
| 91 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 156 | G → C | 0.002545 | SNP | Missense Mutation | GBM |
| 177 | R → C | 0.002020 | SNP | Missense Mutation | PRAD |
| 177 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 196 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 196 | R → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 210 | R → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 217 | C → Y | 0.027027 | SNP | Missense Mutation | DLBC |
| 217 | C → C | 0.001969 | SNP | Silent | LGG |
| 240 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 265 | S → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 279 | F → C | 0.002545 | SNP | Missense Mutation | GBM |
| 281 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 294 | Y → C | 0.002288 | SNP | Missense Mutation | STAD |
| 335 | R → C | 0.003774 | SNP | Missense Mutation | UCEC |
| 372 | R → C | 0.002506 | SNP | Missense Mutation | COAD |