Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0Y2P0 | CD44 | CD44 antigen (Extracellular matrix receptor … | Homo sapiens (Human) | 287 aa |
Protein Details: H0Y2P0 (CD44)
Protein Information
| Accession | H0Y2P0 |
|---|---|
| Protein Names | CD44 antigen (Extracellular matrix receptor III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (Phagocytic glycoprotein I) |
| Gene Symbol | CD44 |
| Organism | Homo sapiens (Human) |
| Length | 287 aa |
| Isoforms | No isoforms |
| Related PMIDs | 19801377 22496122 29575903 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501RYSISRTEAA11DLCKAFNSTL21PTMAQMEKAL31SIGFETCRYG41FIEGHVVIPR
51-10051IHPNSICAAN61NTGVYILTSN71TSQYDTYCFN81ASAPPEEDCT91SVTDLPNAFD
101-150101GPITITIVNR111DGTRYVQKGE121YRTNPEDIYP131SNPTDDDVSS141GSSSERSSTS
151-200151GGDQDTFHPS161GGSHTTHGSE171SDGHSHGSQE181GGANTTSGPI191RTPQIPEWLI
201-250201ILASLLALAL211ILAVCIAVNS221RRRCGQKKKL231VINSGNGAVE241DRKPSGLNGE
251-287251ASKSQEMVHL261VNKESSETPD271QFMTADETRN281LQNVDMK
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 13 | C-type lectin-like/link domain superfamily Link domain CD44 antigen-like C-type lectin fold | - | - |
GPS-Palm: 0.84
Deep-Palm: 0.64
|
|
| 37 | SWISSPALM DBPTM CYSMODDB | C-type lectin-like/link domain superfamily Link domain CD44 antigen-like Extracellular link domain C-type lectin fold |
HeLa
(29575903)
|
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.65
|
| 57 | - | - | - |
Deep-Palm: 0.29
|
|
| 78 | - | - | - |
Deep-Palm: 0.15
|
|
| 89 | - | - | - |
Deep-Palm: 0.08
|
|
| 215 | - | - | - |
GPS-Palm: 0.96
Deep-Palm: 0.98
|
|
| 224 | - | - | - |
GPS-Palm: 0.87
Deep-Palm: 0.97
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.571
4
cerebral cortex
Specificity: 0.364
4/4 (100.0%)
1
HeLa cell
Specificity: 0.091
1/1 (100.0%)
1
EC cell
Specificity: 0.091
1/1 (100.0%)
1
DU145 cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
4
Cerebral Cortex (Mass)
Specificity: 0.364
4/4 (100.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 28 | C → C | 0.002288 | SNP | Silent | STAD |
| 29 | R → C | 0.001969 | SNP | Missense Mutation | LGG |
| 41 | R → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 199 | S → C | 0.002427 | SNP | Missense Mutation | BLCA |
| 245 | F → C | 0.005618 | SNP | Missense Mutation | PAAD |
| 359 | W → C | 0.002288 | SNP | Missense Mutation | STAD |
| 542 | G → C | 0.002545 | SNP | Missense Mutation | GBM |