Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0Y5K5 | ERGIC3 | Endoplasmic reticulum-Golgi intermediate compartment protein | Homo sapiens (Human) | 397 aa |
Protein Details: H0Y5K5 (ERGIC3)
Protein Information
| Accession | H0Y5K5 |
|---|---|
| Protein Names | Endoplasmic reticulum-Golgi intermediate compartment protein |
| Gene Symbol | ERGIC3 |
| Organism | Homo sapiens (Human) |
| Length | 397 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 31382980 32651440 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XALGKLKQFD11AYPKTLEDFR21VKTCGGATVT31IVSGLLMLLL41FLSELQYYLT
51-10051TEVHPELYVD61KSRGDKLKIN71IDVLFPHMPC81AYLSIDAMDV91AGEQQLDVEH
101-150101NLFKQRLDKD111GIPVSSEAER121HELGKVEVTV131FDPDSLDPDR141CESCYGAEAE
151-200151DIKCCNTCED161VREAYRRRGW171AFKNPDTIEQ181CRREGFSQKM191QEQKNEGCQV
201-250201YGFLEVNKVA211GNFHFAPGKS221FQQSHVHGCV231CRLKMIARSL241ACVHDLQSFG
251-300251LDNINMTHYI261QHLSFGEDYP271GIVNPLDHTN281VTAPQASMMF291QYFVKVVPTV
301-350301YMKVDGEVLR311TNQFSVTRHE321KVANGLLGDQ331GLPGVFVLYE341LSPMMVKLTE
351-397351KHRSFTHFLT361GVCAIIGGMF371TVAGLIDSLI381YHSARAIQKK391IDLGKTT
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 24 | Endoplasmic reticulum vesicle transporter, N-terminal Endoplasmic reticulum vesicle transporter | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.95
|
|
| 80 | - | - | - |
Deep-Palm: 0.18
|
|
| 141 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.08
|
|
| 144 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.02
|
|
| 154 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.04
|
|
| 155 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.04
|
|
| 158 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.16
|
|
| 181 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.80
Deep-Palm: 0.43
|
|
| 198 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.35
|
|
| 229 | - | - | - |
GPS-Palm: 0.67
Deep-Palm: 0.30
|
|
| 231 | - | - | - |
GPS-Palm: 0.72
Deep-Palm: 0.48
|
|
| 242 | - | - | - |
GPS-Palm: 0.82
Deep-Palm: 0.51
|
|
| 363 | - | - | - |
Deep-Palm: 0.52
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.364
4
LNCaP
Specificity: 0.333
4/4 (100.0%)
4
PC3
Specificity: 0.333
4/4 (100.0%)
1
U937 cell
Specificity: 0.083
1/1 (100.0%)
1
HeLa cell
Specificity: 0.083
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.083
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.083
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 141 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 141 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 155 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |