Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0Y621 | ERGIC3 | Endoplasmic reticulum-Golgi intermediate compartment protein | Homo sapiens (Human) | 326 aa |
Protein Details: H0Y621 (ERGIC3)
Protein Information
| Accession | H0Y621 |
|---|---|
| Protein Names | Endoplasmic reticulum-Golgi intermediate compartment protein |
| Gene Symbol | ERGIC3 |
| Organism | Homo sapiens (Human) |
| Length | 326 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 32651440 32944167 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | SwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XAYPKTLEDF11RVKTCGGATV21TIVSGLLMLL31LFLSELQYYL41TTEVHPELYV
51-10051DKSRGDKLKI61NIDVLFPHMP71CAWSQYLSLI81FLLPDLSIDA91MDVAGEQQLD
101-150101VEHNLFKQRL111DKDGIPVSSE121AERHELGKVE131VTVFDPDSLD141PDRCESCYGA
151-200151EAEDIKCCNT161CEDVREAYRR171RGWAFKNPDT181IEQCRREGFS191QKMQEQKNEG
201-250201CQVYGFLEVN211KVAGNFHFAP221GKSFQQSHVH231VHDLQSFGLD241NINMTHYIQH
251-300251LSFGEDYPGI261VNPLDHTNVT271APQASMMFQY281FVKVVPTVYM291KVDGEVLRTN
301-326301QFSVTRHEKV311ANGLLGDQGL321PGVFVL
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 15 | Endoplasmic reticulum vesicle transporter, N-terminal | - | - |
GPS-Palm: 0.78
Deep-Palm: 0.98
|
|
| 71 | - | - | - |
Deep-Palm: 0.42
|
|
| 144 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.08
|
|
| 147 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.02
|
|
| 157 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.04
|
|
| 158 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.04
|
|
| 161 | - | - | - |
GPS-Palm: 0.73
Deep-Palm: 0.16
|
|
| 184 | - | - |
LNCaP
(31251020)
|
GPS-Palm: 0.80
Deep-Palm: 0.43
|
|
| 201 | - | - |
LNCaP
(31251020)
|
Deep-Palm: 0.35
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.400
4
LNCaP
Specificity: 0.364
4/4 (100.0%)
4
PC3
Specificity: 0.364
4/4 (100.0%)
1
HeLa cell
Specificity: 0.091
1/1 (100.0%)
1
Jurkat T cell
Specificity: 0.091
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 1.000
1
LNCaP cells (Mass)
Specificity: 0.091
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 48 | Y → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 141 | R → C | 0.002294 | SNP | Missense Mutation | OV |
| 141 | R → C | 0.002141 | SNP | Missense Mutation | SKCM |
| 155 | C → Y | 0.001887 | SNP | Missense Mutation | UCEC |