Search Database
Select Protein (1 found)
| UniProt ID | Gene Symbol | Protein Name | Organism | Length | Action |
|---|---|---|---|---|---|
| H0Y7C1 | ATP1A2 | Sodium/potassium-transporting ATPase subunit alpha | Homo sapiens (Human) | 714 aa |
Protein Details: H0Y7C1 (ATP1A2)
Protein Information
| Accession | H0Y7C1 |
|---|---|
| Protein Names | Sodium/potassium-transporting ATPase subunit alpha |
| Gene Symbol | ATP1A2 |
| Organism | Homo sapiens (Human) |
| Length | 714 aa |
| Isoforms | No isoforms |
| Related PMIDs | 29575903 31251020 36430497 31251020 (mass) 32651440 (mass) 36430497 (mass) |
| Database Sources | CysModDBdbPTMSwissPalm |
These studies detected palmitoylation of this protein in the samples.
Protein Sequence
Types:
Experimental Database High Prediction Non-palmitylated Cys
Experimental Database High Prediction Non-palmitylated Cys
1-501XQLITGVAVF11LGVSFFVLSL21ILGYSWLEAV31IFLIGIIVAN41VPEGLLATVT
51-10051VCLTLTAKRM61ARKNCLVKNL71EAVETLGSTS81TICSDKTGTL91TQNRMTVAHM
101-150101WFDNQIHEAD111TTEDQSGATF121DKRSPTWTAL131SRIAGLCNRA141VFKAGQENIS
151-200151VSKRDTAGDA161SESALLKCIE171LSCGSVRKMR181DRNPKVAEIP191FNSTNKYQLS
201-250201IHEREDSPQS211HVLVMKGAPE221RILDRCSTIL231VQGKEIPLDK241EMQDAFQNAY
251-300251MELGGLGERV261LGFCQLNLPS271GKFPRGFKFD281TDELNFPTEK291LCFVGLMSMI
301-350301DPPRAAVPDA311VGKCRSAGIK321VIMVTGDHPI331TAKAIAKGVG341IISEGNETVE
351-400351DIAARLNIPM361SQVNPREAKA371CVVHGSDLKD381MTSEQLDEIL391KNHTEIVFAR
401-450401TSPQQKLIIV411EGCQRQGAIV421AVTGDGVNDS431PALKKADIGI441AMGISGSDVS
451-500451KQAADMILLD461DNFASIVTGV471EEGRLIFDNL481KKSIAYTLTS491NIPEITPFLL
501-550501FIIANIPLPL511GTVTILCIDL521GTDMVPAISL531AYEAAESDIM541KRQPRNSQTD
551-600551KLVNERLISM561AYGQIENGFL571PSRLLGIRLD581WDDRTMNDLE591DSYGQEWTYE
601-650601QRKVVEFTCH611TAFFASIVVV621QWADLIICKT631RRNSVFQQGM641KNKILIFGLL
651-700651EETALAAFLS661YCPGMGVALR671MYPLKVTWWF681CAFPYSLLIF691IYDEVRKLIL
701-714701RRYPGGWVEK711ETYY
Palmitoylation Sites Details
| Position | Database | Domains | Literature (PMID/Cell-Tissue) | Mass(PMID/Cell-Tissue) | Prediction Scores |
|---|---|---|---|---|---|
| 52 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.97
|
|
| 65 | - | - | - |
GPS-Palm: 0.93
Deep-Palm: 0.96
|
|
| 83 | - | - |
LNCaP
(31251020)
Unknown
(32651440)
cerebral cortex
(36430497)
|
GPS-Palm: 0.76
Deep-Palm: 0.98
|
|
| 137 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.87
Deep-Palm: 0.95
|
|
| 168 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.67
Deep-Palm: 0.95
|
|
| 173 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.91
Deep-Palm: 0.96
|
|
| 226 | - | - |
cerebral cortex
(36430497)
LNCaP
(31251020)
|
GPS-Palm: 0.79
Deep-Palm: 0.98
|
|
| 264 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.89
Deep-Palm: 0.96
|
|
| 292 | - | - | - |
Deep-Palm: 0.57
|
|
| 314 | - | - | - |
GPS-Palm: 0.86
Deep-Palm: 0.95
|
|
| 371 | - | - |
cerebral cortex
(36430497)
|
GPS-Palm: 0.80
Deep-Palm: 0.89
|
|
| 413 | SWISSPALM DBPTM CYSMODDB | - | - |
LNCaP
(31251020)
cerebral cortex
(36430497)
|
GPS-Palm: 0.95
Deep-Palm: 0.90
|
| 517 | - | - | - |
Deep-Palm: 0.97
|
|
| 609 | - | - | - |
Deep-Palm: 0.09
|
|
| 628 | - | - | - |
GPS-Palm: 0.92
Deep-Palm: 0.58
|
|
| 662 | - | - | - |
GPS-Palm: 0.88
Deep-Palm: 0.98
|
|
| 681 | - | - | - |
Deep-Palm: 0.36
|
Score Interpretation:
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
• GPS-Palm: Thresholds - High (≥0.8920), Medium (≥0.7766), Low (≥0.6484), Very Low (<0.6484)
• Deep-Palm: Higher score indicates higher probability of palmitoylation (High ≥0.9)
Tissue/Cell Line Expression
Literature Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.500
4
cerebral cortex
Specificity: 0.308
4/4 (100.0%)
3
LNCaP
Specificity: 0.231
3/3 (100.0%)
1
HeLa cell
Specificity: 0.077
1/1 (100.0%)
Mass Spectrometry Data - Tissue/Cell Line Expression
Tissue Specificity Index (TSI): 0.800
4
Cerebral Cortex (Mass)
Specificity: 0.308
4/4 (100.0%)
1
LNCaP cells (Mass)
Specificity: 0.077
1/4 (25.0%)
Palmitoylation Distribution by Study and Tissue/Cell Line
Chart Explanation: Each bar represents a study (PMID).
Blue bars: Literature data, Orange bars: Mass Spectrometry data.
The colored bottom segment shows palmitoylated samples, while the gray top segment shows non-palmitoylated samples.
Conservation score for cysteine
PhyloP for Cysteine
PhastCons Conservation Scores for Cysteine
TCGA Cysteine Mutation Information
Note: Mutations indicate amino acid changes that may create potential palmitoylation sites.
| Position | Amino Acid Change | Frequency | Type | Function | Cancer Type |
|---|---|---|---|---|---|
| 51 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 143 | C → G | 0.002506 | SNP | Missense Mutation | COAD |
| 247 | C → C | 0.002033 | SNP | Silent | LUSC |
| 267 | R → C | 0.002288 | SNP | Missense Mutation | STAD |
| 267 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 428 | R → C | 0.002506 | SNP | Missense Mutation | COAD |
| 486 | Y → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 510 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |
| 548 | R → C | 0.002976 | SNP | Missense Mutation | KIRC |
| 664 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 861 | G → C | 0.001764 | SNP | Missense Mutation | LUAD |
| 861 | G → C | 0.001887 | SNP | Missense Mutation | UCEC |
| 976 | R → C | 0.001969 | SNP | Missense Mutation | HNSC |